61940-07-6Relevant academic research and scientific papers
Study on the iodine-catalyzed reaction of 3-aminopyrazine-2-carbohydrazide and 2-(arylethynyl)benzaldehydes
Pan, Wan-Chen,Liu, Jian-Quan,Wang, Xiang-Shan
, p. 1468 - 1475 (2018/02/19)
At 60 °C in DMSO, the iodine-catalyzed reaction of 3-aminopyrazine-2-carbohydrazide and 2-(arylethynyl)benzaldehydes led hydrazones. Increasing the reaction temperature to 100 °C, the amino and amido still indicated inactive, only the imine took part in the addition of acetylene bond to give 2-arylisoquinolines in high yields with the cleavage of N-N bond unexpectedly under metal-free conditions.
Process for the preparation of thieno(3,2-c) pyridine and derivatives thereof
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, (2008/06/13)
This invention relates to a process for the preparation of compounds having the formula: STR1 in which R1 is H or lower alkyl and R2 is H or lower alkyl, or phenyl or benzyl optionally substituted with at least one halogen or a lower alkyl, lower alkoxy, trifluoromethyl or nitro group. According to this method, a compound of the formula: STR2 in which R1 and R2 are as defined above and R3 is H or optionally substituted alkyl or benzyl, is reacted with a derivative Hal--SO2 --R (III) in which Hal is halogen and R is optionally substituted alkyl, aryl or aralkyl, to give a derivative of the formula: STR3 in which the various symbols have the above-defined meanings, and the sulfonated derivative of the formula (IV) is heated in the presence of an acid, to give the compound of the formula (I).
