61941-35-3Relevant academic research and scientific papers
Geminal Diphosphonic Acids Containing Amidino Groups
Worms, Karl-Heinz,Blum, Helmut
, p. 275 - 281 (2007/10/02)
The reaction of amides or nitriles with H3PO4/PCl3 leads in some cases to the formation of amidinoalkylidenediphophonic acids.In the case of formamide under specified conditions, amidinomethylenediphosphonic acid (4) is formed, with succin- or glutaramides (or with the nitriles) the heterocyclic, geminal diphosphonic acids 10 are obtained.By the reaction of 2-pyrrolidinone 12 with PCl3/H2O in addition to the expected 2,2-pyrrolidinylidenediphosphonic acid (11a) an amidine is isolated, for which the structure 15 is suggested.The alkaline hydrolyses of these compounds and the corresponding reaction products are described.
