61941-46-6

Usage

Uses

Used in Pharmaceutical Industry:
2-Methoxy-5-Nitroacetophenone is used as a synthetic intermediate for the production of various pharmaceuticals. Its unique chemical structure allows it to be a versatile building block in the synthesis of a range of medicinal compounds, contributing to the development of new drugs and therapies.
Used in Dye and Pigment Production:
In the dye and pigment industry, 2-Methoxy-5-Nitroacetophenone is utilized as a key component in the manufacturing process. Its chemical properties make it suitable for creating a variety of dyes and pigments, which are used in different applications such as textiles, plastics, and printing inks.
Used in Organic Chemistry Research:
2-Methoxy-5-Nitroacetophenone is employed as a research compound in organic chemistry. Its reactivity and structural features make it an interesting subject for studies aimed at understanding chemical reactions and developing new synthetic methods.
Used in Solvent Applications:
Due to its solubility in various organic solvents, 2-Methoxy-5-Nitroacetophenone can be used in applications where its solubility properties are advantageous, such as in the formulation of certain types of solvents or as a component in specialized solutions.

Upstream product

• 1450-76-6 1-(2-hydroxy-5-nitrophenyl)ethanone 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 90763-46-5 2-methoxy-5-nitrobenzoyl chloride 

Downstream Products

• 1056638-81-3 (2E)-3-(dimethylamino)-1-(2-methoxy-5-nitrophenyl)prop-2-en-1-one 
• 1450-76-6 1-(2-hydroxy-5-nitrophenyl)ethanone 
• 168637-39-6 2-methoxy-5-nitrophenacyl bromide 

Relevant academic research and scientific papers

ANTIFUNGAL AGENTS

Compounds of formula (I), and pharmaceutically acceptable salts thereof, may be used in therapy, for example as antifungal agents: (I) wherein: Rl, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. Certain compounds of formula (I) are also provided. Compounds of formula (T), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.

Rate of Enolate Formation Is Not Very Sensitive to the Hydrogen Bonding Ability of Donors to Carboxyl Oxygen Lone Pair Acceptors; A Ramification of the Principle of Non-Perfect Synchronization for General-Base-Catalyzed Enolate Formation

Two series of structures (1 and 2) possessing intramolecular hydrogen bonds to the lone-pair electrons of carbonyl oxygens have been examined to reveal the influence of the pKa of the hydrogen-bond donor on the rate of general-base-catalyzed enolate formation. The geometry of the hydrogen bonds is well accepted to be appropriate for intramolecular hydrogen-bond formation. Yet, as revealed by Bronsted plots, both series show very little dependence of the rate of enolate formation on the hydrogen-bond donor ability. The intramolecular hydrogen bonds give rate enhancements only on the order of 10-100-fold, and corrected Bronsted α-values are slightly below 0.1. The results can be understood by interpreting them in light of the Principle of Non-Perfect Synchronization. The results are consistent with the proton transfer occurring through an asynchronous transition state with the developing negative charge localized on carbon. We postulate that catalysts of enolate formation will be most effective if the binding groups are focused on stabilizing negative charge that is forming on the enolate carbon rather than on the enolate oxygen.

Tricyclic compounds and drug compositions containing the same

Compounds having a β-3 adrenaline receptor agonist and are useful as drugs for the treatment and prevention of diabetes, obesity, hyperlipemia, etc., represented by a general formula (I) and salts thereof, and a process for producing these, and their intermediates, wherein R represents hydrogen or methyl; R1 represents hydrogen, halogen, hydroxy, benzyloxy, amino, or hydroxymethyl; R2 represents hydrogen, hydroxymethyl, NHR3, SO2 NR4 R4', or nitro; R6 represents hydrogen or lower alkyl; and X represents nitrogen, R9 represents hydrogen, one of R7 and R8 represent hydrogen, and the other thereof represents hydrogen, amino, acetylamino, or hydroxy.