61941-84-2Relevant academic research and scientific papers
Indomethacin amides as a novel molecular scaffold for targeting trypanosoma cruzi sterol 14α-demethylase
Konkle, Mary E.,Hargrove, Tatiana Y.,Kleshchenko, Yuliya Y.,Von Kries, Jens P.,Ridenour, Whitney,Uddin, Md Jashim,Caprioli, Richard M.,Marnett, Lawrence J.,Nes, W. David,Villalta, Fernando,Waterman, Michael R.,Lepesheva, Galina I.
experimental part, p. 2846 - 2853 (2010/01/16)
Trypanosoma cruzi (TC) causes Chagas disease, which in its chronic stage remains incurable. We have shown recently that specific inhibition of TC sterol 14α-demethylase (TCCYP51) with imidazole derivatives is effective in killing both extracellular and in
