61946-89-2

Usage

Uses

Used in Agricultural Applications:
(Z)-2-CHLORO-2-(4-ETHOXYPHENYL)ETHENOL is used as an insecticide for controlling various pests in agricultural settings. Its application helps protect crops from damage caused by insects, ensuring a higher yield and better quality of produce.
Used in Residential Applications:
(Z)-2-CHLORO-2-(4-ETHOXYPHENYL)ETHENOL is also used as an insecticide in residential settings to control household pests, such as mosquitoes and flies. Its effectiveness in eliminating these insects contributes to a healthier and more comfortable living environment.
Used in Environmental Management:
(Z)-2-CHLORO-2-(4-ETHOXYPHENYL)ETHENOL is employed in environmental management as a tool for controlling insect populations that may pose risks to ecosystems or human health. Its targeted application helps maintain a balance in the ecosystem while minimizing the potential negative impacts on non-target species.

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 61096-94-4 N-[(E)-(4-ethoxyphenyl)methylidene]hydroxylamine 
• 61096-94-4 4-ethoxybenzaldoxime 
• 10031-82-0 4-ethoxybenzaldehyde 

Relevant academic research and scientific papers

Dibenzazepine-linked isoxazoles: New and potent class of α-glucosidase inhibitors

α-Glucosidase inhibition is a valid approach for controlling hyperglycemia in diabetes. In the current study, new molecules as a hybrid of isoxazole and dibenzazepine scaffolds were designed, based on their literature as antidiabetic agents. For this, a series of dibenzazepine-linked isoxazoles (33–54) was prepared using Nitrile oxide-Alkyne cycloaddition (NOAC) reaction, and evaluated for their α-glucosidase inhibitory activities to explore new hits for treatment of diabetes. Most of the compounds showed potent inhibitory potency against α-glucosidase (EC 3.2.1.20) enzyme (IC50 = 35.62 ± 1.48 to 333.30 ± 1.67 μM) using acarbose as a reference drug (IC50 = 875.75 ± 2.08 μM). Structure-activity relationship, kinetics and molecular docking studies of active isoxazoles were also determined to study enzyme-inhibitor interactions. Compounds 33, 40, 41, 46, 48–50, and 54 showed binding interactions with critical amino acid residues of α-glucosidase enzyme, such as Lys156, Ser157, Asp242, and Gln353.

Identification of morpholine based hydroxylamine analogues: Selective inhibitors of MARK4/Par-1d causing cancer cell death through apoptosis

Microtubule affinity-regulating kinase 4 (MARK4) is a serine/threonine kinase involved in the phosphorylation of MAP proteins that regulates microtubule dynamics and abets tumor progression by participating in oncogenic signaling pathways. It is overexpressed in multiple human malignancies and no drug is available for this potential therapeutic target at present. Therefore, using the structure based drug design strategy, a library of hydroxylamine derivatives of morpholine were designed and synthesized as small molecule inhibitors of MARK4. Compound 32 having the CF3 group at the ortho position of the phenyl ring tethered with the >CNOH core and the hinge binder morpholine component was found to be a potent and selective inhibitor of MARK4 over thirty other serine-threonine kinases. Study of cell viability and compound induced morphological changes in MCF-7 cancer cells discovered that molecule 32 caused death of cancerous cells through the mechanism of apoptosis. Compound 32 may be transported and delivered to the target site through the blood stream, and has promising antioxidant potential. Such bio-active molecules could serve as optimized lead candidates in drug discovery for cancer treatment through MARK4 inhibition.

N -Oxide-Controlled Chemoselective Reduction of Nitrofuroxans

A facile and chemoselective SnCl 2 -mediated mild reduction of regioisomeric 3- and 4-nitrofuroxans for the synthesis of aminofurazans and aminofuroxans in good yields is developed. Reduction of 4-nitrofuroxans results in the selective formation of 4-aminofuroxans, while analogous reduction of 3-nitrofuroxans affords 3-aminofurazans as a result of simultaneous reduction of the nitro group and exocyclic N-O bond.

Hydroxamic acid derivatives: a promising scaffold for rational compound optimization in Chagas disease

This work describes the antitrypanocidal activity of two hydroxamic acid derivatives containing o-ethoxy (HAD1) and p-ethoxy (HAD2) as substituent in the aromatic ring linked to the isoxazoline ring. HAD1 and HAD2 induced a significant reduction in the nu

N-(sulfonyloxy) benzimidoyl halides as bactericidal or fungicidal agents

Agricultural fungicidal compositions based on N-(sulfonyloxy)benzimidoyl halides exhibit a broad spectrum of antifungal activity, particularly against late blight, bean rust and rice blast. The synthesis of representative compounds is described, and the utility of antifungal compositions is exemplified.