61954-80-1

Basic information

• Product Name: 5-BROMO-2-MERCAPTOBENZOIC ACID
• Synonyms: 5-BROMO-2-MERCAPTOBENZOIC ACID;Benzoic acid, 5-broMo-2-Mercapto-
• CAS NO: 61954-80-1
• Molecular Formula: C₇H₅BrO₂S
• Molecular Weight: 233.08
• Mol File: 61954-80-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 5-BROMO-2-MERCAPTOBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-MERCAPTOBENZOIC ACID(61954-80-1)
• EPA Substance Registry System: 5-BROMO-2-MERCAPTOBENZOIC ACID(61954-80-1)

Safety Data

• Hazardous Substances Data: 61954-80-1(Hazardous Substances Data)

Usage

General Description

5-Bromo-2-mercaptobenzoic acid is a compound with the molecular formula C7H5BrO2S. It is a derivative of benzoic acid and contains a bromine and a thiol (sulfhydryl) group. This chemical is used in various fields, including pharmaceuticals, agrochemicals, and material science. It has been researched for its potential use in the synthesis of pharmaceutical compounds and as a building block for organic molecules. Its properties make it suitable for use as a reagent in organic synthesis and as a potential therapeutic agent. It is important to handle this chemical with care and under appropriate safety measures due to its potential hazards.

Upstream product

• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 140-89-6 potassium ethyl xanthogenate 
• 179897-89-3 5-Bromo-2-fluoro-benzonitrile 
• 1374518-00-9 5-bromo-2-mercaptobenzonitrile 

Downstream Products

• 99067-28-4 5-bromo-2-carboxymethylsulfanyl-benzoic acid 
• 16220-63-6 5-bromo-2-(2-thienylmethylthio)benzoic acid 
• 100540-90-7 bis(2-hydroxycarbonyl-4-bromophenyl) disulfide 
• 62176-40-3 5-bromo-2-(methylthio)benzoic acid 
• 881900-09-0 methyl 5-bromo-2-mercaptobenzoate 
• 881900-10-3 methyl 5-bromo-2-[(cyanomethyl)thio]benzoate 
• 881900-11-4 5-bromo-3-hydroxy-1-benzothiophene-2-carbonitrile 
• 881900-12-5 3-hydroxy-5-phenyl-1-benzothiophene-2-carbonitrile 
• 944061-13-6 2-[(5-bromo-2-cyano-1-benzothien-3-yl)oxy]acetamide 
• 881900-13-6 2-[(2-cyano-5-phenyl-1-benzothien-3-yl)oxy]acetamide 
• 881899-88-3 3-amino-7-phenyl[1]benzothieno[3,2-b]furan-2-carboxamide 
• 638205-05-7 3-benzyl-6-bromo-3,4-dihydro-benzothiazine-2,4-dione 
• 1005412-71-4 2-(4'-acetoxymethyl-2'-nitrophenylthio)-5-bromobenzoic acid 
• 1005412-83-8 5-bromo-2-(4'-methyl-2'-nitrophenylthio)benzoic acid 

Relevant articles and documents

BENZOXAZINONE COMPOUNDS AS KLK5/7 DUAL INHIBITORS

The present invention provides compounds and pharmaceutical compositions including the compounds for the treatment of a skin disease associated with proteolytic activity of one or more KLK proteases, wherein the compounds are according to formula (I): whe

Chemical synthesis, crystal structure, versatile evaluation of their biological activities and molecular simulations of novel pyrithiobac derivatives

Since pyrithiobac (PTB) is a successful commercial herbicide with very low toxicity against mammals, it is worth exploring its derivatives for an extensive study. Herein, a total of 35 novel compounds were chemically synthesized and single crystal of 6–6

Synthesis and structure activity relationship studies of benzothieno[3,2-b]furan derivatives as a novel class of IKKβ inhibitors

As a novel class of IKKβ inhibitors, a series of tricyclic furan derivatives was designed and synthesized based on the structure of known thiophene IKKβ inhibitors. Among the various fused furan derivatives synthesized, a benzothieno[3,2-b]furan derivative 13a displayed potent inhibitory activity towards IKKβ in enzymatic and cellular assays. The potent inhibitory activity originates from an intramolecular non-bonded S...O interaction which was confirmed by the X-ray structure of JNK3 with 16k. The introduction of further substituents on the core structure led to the discovery of the 6-alkoxy derivatives, which possessed a comparable IKKβ inhibitory activity to 13a and an improved metabolic stability. Among these, appropriately lipophilic compounds 16a, h, i, and 13g (logD>2) were found to possess good oral bioavailability.