61964-08-7

Basic information

• Product Name: 1,3-Dihydroisobenzofuran-5-ylamine
• Synonyms: 1,3-DIHYDROISOBENZOFURAN-5-AMINE;4-PHENYLPHTHALONITRILE;1,3-Dihydro-2-benzofuran-5-amine;1,3-Dihydroisobenzofuran-5-ylamine;5-Amino-1,3-dihydrobenzo[c]furan;1,3-dihydro-2-benzofuran-5-amine(SALTDATA: FREE);5-AMinophthalan;1,3-Dihydro-2-benzofuran-5-amine, 5-Amino-1,3-dihydro-2-benzofuran
• CAS NO: 61964-08-7
• Molecular Formula: C₈H₉NO
• Molecular Weight: 135.16
• Mol File: 61964-08-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 104-105 °C
• Boiling Point: 295.905 °C at 760 mmHg
• Flash Point: 156.803 °C
• Appearance: /
• Density: 1.208g/cm³
• Vapor Pressure: 3.8E-07mmHg at 25°C
• Refractive Index: 1.631
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.79±0.20(Predicted)
• CAS DataBase Reference: 1,3-Dihydroisobenzofuran-5-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dihydroisobenzofuran-5-ylamine(61964-08-7)
• EPA Substance Registry System: 1,3-Dihydroisobenzofuran-5-ylamine(61964-08-7)

Safety Data

• Hazardous Substances Data: 61964-08-7(Hazardous Substances Data)

Usage

General Description

1,3-Dihydroisobenzofuran-5-ylamine is a chemical compound that belongs to the class of amines. It has a molecular formula C10H11NO and a molecular weight of 161.20 g/mol. 1,3-Dihydroisobenzofuran-5-ylamine is an aromatic amine derivative and contains a 1,3-dihydroisobenzofuran-5-yl group. It is commonly used in the field of organic chemistry as a building block for the synthesis of various pharmaceuticals and agrochemicals. The compound is also known for its potential biological activities and is being studied for its therapeutic applications. Additionally, it has shown potential as a reagent in organic synthesis and as a precursor in the production of other chemical compounds.

InChI:InChI=1/C14H8N2/c15-9-13-7-6-12(8-14(13)10-16)11-4-2-1-3-5-11/h1-8H

Upstream product

• 52771-99-0 5-nitro-1,3-dihydroisobenzofuran 
• 496-14-0 1,3-dihydroisobenzofuran 

Downstream Products

• 220513-49-5 5-bromo-1,3-dihydroisobenzofuran 
• 1391598-74-5 2-{2-[2-(1,3-dihydro-isobenzofuran-5-ylamino)-pyrimidin-4-yl]-pyridin-4-yl}-benzamide 
• 1391602-23-5 N-(1,3-dihydro-isobenzofuran-5-yl)-guanidine tosylate 
• 944447-36-3 6-(2,6-dichlorophenyl)-2-[(1,3-dihydro-5-isobenzo-furanyl)amino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one 

Relevant articles and documents

6-MEMBERED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

A compound represented by Formula (I): wherein or the like Y1 is O or the like; Z1 is C(R4) or N; Z2a is C(R5a) or the like; Z3a is C(R6) or the like; R4, R5a and R6 are each independently a hydrogen atom or the like; R1 is substituted or unsubstituted aromatic carbocyclyl or the like; R2a, R2b, R2c and R2d are each independently a hydrogen atom or the like; X is N(R7a) or the like; R7a is a hydrogen atom or the like; R3 is or the like Ring B is a 6-membered aromatic carbocycle or the like; R9a and R10a are each independently halogen or the like; n is an integer from 1 to 5; m is an integer from 0 to 4; and p1 is an integer from 0 to 3, or a pharmaceutically acceptable salt thereof.

COMPOUNDS AND METHODS FOR TREATING DYSLIPIDEMIA

Compounds of formula I wherein n, m, p, q, Y, R1 R2, R3, R4, R5, and R6 are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating artherosclerosis and its sequelae.

Synthesis and analgesic activity of 1,3-dihydro-3-(substituted phenyl)imidazo[4,5-6]pyridin-2-ones and 3-(substituted phenyl)-1,2,3-triazolo[4,5-b]pyridines

In a study of nonsteroidal antiinflammatory and analgesic agents, a series of 1,3-dihydro-3-(substituted phenyl)imidazo[4,5-b]pyridin-2-ones and 3-(substituted phenyl)triazolo[4,5-b]pyridines was prepared. Many of the imidazolones were alkylated on the free nitrogen. In a modified Randall-Selitto analgesic assay, the pain thresholds of both the inflamed and normal foot were elevated. This is not commonly observed with nonsteroidal antiinflammatory agents. The most active compounds were 1,3-dihydro-3-[3,4-(methylenedioxy)phenyl]imidazo[4,5-b]pyridin-2-one (I-15) and its N-allyl (I-21) and N-isopropyl (I-121) derivatives. In the triazole series the 3-(2-fluoro- and 2,4-difluorophenyl)triazolo[4,5-b]pyridines (T-1 and T-8) were the best. The imidazole compounds were somewhat superior in analgesic activity to codeine and d-propoxyphene without showing any narcotic characteristics. Some of the compounds also possessed activity against carrageenan-induced foot edema in the rat, so these compounds represent a new class of nonnarcotic analgesic antiinflammatories, capable of producing a greater degree of analgesia than that obtainable with other nonsteroidal antiinflammatory agents.