61965-96-6

Basic information

• Product Name: Benzenepropanoic acid, 3-fluoro-a-nitro-, ethyl ester
• CAS NO: 61965-96-6
• Molecular Formula: C11H12FNO4
• Molecular Weight: 241.219
• Mol File: 61965-96-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, 3-fluoro-a-nitro-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, 3-fluoro-a-nitro-, ethyl ester(61965-96-6)
• EPA Substance Registry System: Benzenepropanoic acid, 3-fluoro-a-nitro-, ethyl ester(61965-96-6)

Safety Data

• Hazardous Substances Data: 61965-96-6(Hazardous Substances Data)

Upstream product

• 456-48-4 3-Fluorobenzaldehyde 
• 32347-92-5 α,α-dimethoxy-m-fluorotoluene 

Relevant articles and documents

Synthesis of unnatural α-amino esters using ethyl nitroacetate and condensation or cycloaddition reactions

We report here on the use of ethyl nitroacetate as a glycine template to produce α-amino esters. This started with a study of its condensation with various arylacetals to give ethyl 3-aryl-2-nitroacrylates followed by a reduction (NaBH4 and then zinc/HCl) into α-amino esters. The scope of this method was explored as well as an alternative with arylacylals instead. We also focused on various [2 + 3] cycloadditions, one leading to a spiroacetal, which led to the undesired ethyl 5-(benzamidomethyl)isoxazole-3-carboxylate. The addition of ethyl nitroacetate on a 5-methylene-4,5-dihydrooxazole using cerium(IV) ammonium nitrate was also explored and the synthesis of other oxazole-bearing α-amino esters was achieved using gold(I) chemistry.