61966-08-3 Usage
Description
Triciribine, also known as 3-(3-pyridin-3-yl-1H-pyrazol-4-yl)pyridine, is a small molecule inhibitor that targets the Akt signaling pathway. It functions by binding to the pleckstrin homology (PH) domain of Akt, thereby inhibiting Akt phosphorylation and blocking its recruitment to the plasma membrane. This action results in the suppression of downstream signaling pathways involved in cell survival, growth, and proliferation.
Uses
Used in Pharmaceutical Industry:
Triciribine is used as an Akt activation inhibitor for its potential role in cancer therapy. By inhibiting the Akt pathway, Triciribine can disrupt the survival and proliferation of cancer cells, making it a promising candidate for the development of targeted cancer treatments.
Additionally, Triciribine may be used in research applications to study the role of the Akt signaling pathway in various cellular processes and diseases. Its ability to selectively inhibit Akt activation can provide valuable insights into the mechanisms underlying the regulation of cell growth, survival, and metabolism.
Check Digit Verification of cas no
The CAS Registry Mumber 61966-08-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,9,6 and 6 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 61966-08:
(7*6)+(6*1)+(5*9)+(4*6)+(3*6)+(2*0)+(1*8)=143
143 % 10 = 3
So 61966-08-3 is a valid CAS Registry Number.
InChI:InChI=1/C13H17N6O7P/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(21)8(20)6(26-13)3-25-27(22,23)24/h2,4,6,8-9,13,20-21H,3H2,1H3,(H2,14,17)(H2,22,23,24)
