61972-52-9Relevant academic research and scientific papers
CYCLIZATION OF 2-(Γ-BROMOACETOACETAMIDO)PYRIDINE DERIVATIVES: FORMATION OF N-ARYL-Γ-LACTAM DERIVATIVES
Tabei, Katsumi,Ito, Hideharu,Takada, Toyozo
, p. 1779 - 1784 (2007/10/02)
1-(2-Pyridil)-4-hydroxy-2-pyrrolidone (7) was obtained from 2-(γ-bromoacetoacetamido)pyridine (1) through the reduction of the β-carbonyl group with NaBH4, protection of the hydroxyl group by tetrahydropyranyl group, cyclization of the ether to a γ-lactam by using DBU, and subsequent hydrolysis of the ether.According to the similar synthetic process, 1-phenyl-4-hydroxy-2-pyrrolidone (8a) and 1-(p-methoxyphenyl)-4-hydroxy-2-pyrrolidone (8b) were derived from the corresponding γ-bromoacetoacetanilide derivatives.
