61997-80-6

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 126-81-8 dimedone 

Downstream Products

• 73825-37-3 3-[Ethyl-(2-methoxy-phenyl)-amino]-5,5-dimethyl-cyclohex-2-enone 
• 1154040-31-9 1-(2-methoxyphenyl)-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione 
• 1401912-84-2 5,10-dihydro-5-(2-methoxyphenyl)-6,7-dimethyl-10-oxoindeno[1,2-b]indol-9-yl acetate 
• 1401912-90-0 5,10-dihydro-5-(2-methoxyphenyl)-6,7-dimethyl-10-oxoindeno[1,2-b]indol-9-yl propionate 
• 1579950-48-3 6,6-dimethyl-1-(2-methoxyphenyl)-6,7-dihydrospiro[indole-3,1'-isoindoline]-2,3',4(1H,5H)-trione 

Relevant academic research and scientific papers

Silica-supported LiHSO4 as a highly efficient, heterogeneous and reusable catalytic system for the solvent-free synthesis of β-enaminones and β-enamino esters

A highly efficient, simple and green procedure for the synthesis of β-enaminones and β-enamino esters is described. The reaction of aromatic and aliphatic amines with β-dicarbonyl compounds using catalytic amount of silica-supported LiHSO4 (LiHSO4/SiO2) under solvent-free conditions at 80 °C affords the title compounds in high to excellent yields and in short reaction times.

Synthesis, crystal structure and effect of indeno[1,2-b]indole derivatives on prostate cancer in vitro. Potential effect against MMP-9

A highly regiospecific synthesis of a series of indenoindoles is reported, together with X-ray studies and their activity against human prostate cancer cells PC-3 and LNCaP in vitro. The most effective compound 7,7-dimethyl-5-[(3,4-dichlorophenyl)]-(4bRS,9bRS)-dihydroxy-4b,5,6,7,8,9bhexahydro-indeno[1,2-b]indole-9,10-dione 7q reduced the viability in both cell lines in a time and dose-dependent manner. Inhibitory effects were also observed on the adhesion, migration, and invasion of the prostate cancer cells as well as on clonogenic possibly by inhibition of MMP-9 activity. Molecular docking of 7q and 6k into MMP-9 human active site was also performed to determine the probable binding mode.

Silica sulfuric acid-mediated synthesis of β-enaminones and β-enaminoesters under microwave irradiation

Silica sulfuric acid, a heterogeneous reagent, has been found to be an efficient catalyst for the synthesis of β-enaminones and β-enaminoesters under microwave irradiation in a microwave reactor within 2 min. The experimental procedure is simple and environment-friendly, and results in excellent yields of the products. Further, the catalyst is recyclable, and the reaction is 60 times faster than the reaction at room temperature. Copyright Taylor & Francis Group, LLC.

Molecular iodine-catalyzed mild and effective synthesis of β-enaminones at room temperature

Molecular iodine has been found to be an efficient and ecofriendly catalyst for the synthesis of β-enaminones from dimedone and amines at room temperature in the presence of acetonitrile within 60 min. The experimental procedure is simple, includes shorter reaction times, and results in excellent yields of the products. Copyright

Zeolite (ZSM-5) as a highly efficient and heterogeneous catalyst for the synthesis of β-Enaminones and β-Enamino esters

Several β-enaminones and β-enaminoesters have been synthesized in high yields from amine and β-diketone in the presence of Zeolite (ZSM-5) as a catalyst. This method is applicable to both cyclic and acyclic ketones with aromatic and aliphatic amines. Copyright E-Journal of Chemistry 2004-2011.

A green solventless protocol for the synthesis of β-Enaminones and β -Enamino esters using silica sulfuric acid as a highly efficient, heterogeneous and reusable catalyst

Silica sulfuric acid is utilized as a green, highly efficient, heterogeneous and recyclable catalyst for the preparation of β-enaminones and β -enamino esters from amines and β -dicarbonyl compounds under solvent-free conditions at 80 °C. Using this method, the title compounds are produced in high to excellent yields and in short reaction times.

Intramolecular Cyclization of Enaminones Involving Arylpalladium Complexes. Synthesis of Carbazoles

On treatment of the 3-((2-bromoaryl)amino)cyclohex-2-en-1-ones with a catalytic amount of Pd(0) species, intramolecular cyclization via arylpalladium complexes occurred to yield the 1,2-dihydrocarbazol-4(3H)-ones.Analogous products were also obtained by a