61999-50-6

Basic information

• Product Name: 2-Azetidinone, 1-(3-methoxyphenyl)-
• Synonyms: N-(3-methoxyphenyl)azetidin-2-one;2-Azetidinone,1-(3-methoxyphenyl)
• CAS NO: 61999-50-6
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.203
• Mol File: 61999-50-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 66-67 °C
• Boiling Point: 404.2±28.0 °C(Predicted)
• Density: 1?+-.0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-Azetidinone, 1-(3-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Azetidinone, 1-(3-methoxyphenyl)-(61999-50-6)
• EPA Substance Registry System: 2-Azetidinone, 1-(3-methoxyphenyl)-(61999-50-6)

Safety Data

• Hazardous Substances Data: 61999-50-6(Hazardous Substances Data)

Upstream product

• 1216002-27-5 3-bromo-N-(3-methoxyphenyl)propanamide 
• 536-90-3 m-Anisidine 
• 930-21-2 2-azetidinone 
• 766-85-8 3-methoxy-1-iodobenzene 
• 75227-24-6 ethyl 3-(3-methoxyphenylamino)propionate 

Downstream Products

• 879-56-1 7-Methoxy-2,3-dihydro-1H-quinolin-4-one 
• 61999-48-2 5-methoxy-2,3-dihydroquinolin-4(1H)-one 
• 190516-85-9 7-methoxy-4(1H)-oxoquinoline 
• 179897-99-5 1-tert-butoxycarbonyl-1,2,3,4-tetrahydro-7-methyloxy-4-quinolinone 

Relevant articles and documents

Asymmetric Synthesis of Cyclopentene-Fused Tetrahydroquinolines via N-Heterocyclic Carbene Catalyzed Domino Reactions

A new strategy for the N-heterocyclic carbene catalyzed asymmetric synthesis of cyclopentene-fused tetrahydroquinoline derivatives has been developed. The one-pot organocatalytic domino protocol allows a direct entry to the characteristic cyclopenta[ c ]tetrahydroquinoline core of many alkaloids and some potential drugs employing readily available quinolinone and enal substrates in good domino yields and stereoselectivities.

Formation of 2,3-Dihydro-4(1H)-quinolones and Related Compounds via Fries-type Acid-catalysed Rearrangement of 1-Arylazetidin-2-ones

A variety of 1-arylazetidin-2-ones were treated with trifluoroacetic acid under reflux, methanesulphonic acid at 100 deg C, or conc. sulphuric acid to give the corresponding 2,3-dihydro-4(1H)-quinolones via acyl migration and N-CO fission.In the case of 1-(3-substituted phenyl)azetidin-2-ones, two positional isomeric products, 5- and 7-substituted 2,3-dihydro-4(1H)-quinolones were obtained. 4-Methyl, 4-ethoxycarbonyl, and 4-piperidin-2-yl-1-arylazetidin-2-ones and their analogues were also converted into the corresponding 2-substituted 2,3-dihydro-4(1H)-quinolones under acidic conditions.The 3-substituted 1-phenylazetidin-2-ones (36) and (37) were converted into the furoquinoline systems (38) and (40), respectively, by application of this method.