6200-60-8

Usage

Uses

Used in Pharmaceutical Industry:
IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID is used as an anti-cancer agent for its ability to inhibit the PAK1 enzyme, which is implicated in cancer cell growth and metastasis. Its targeted action on PAK1 may lead to the disruption of processes that facilitate tumor progression, offering a potential therapeutic strategy for cancer treatment.
Used in Inflammatory Disease Treatment:
IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID is used as an anti-inflammatory agent due to its capacity to reduce the production of inflammatory cytokines. This property suggests its potential utility in managing inflammatory conditions by mitigating the immune response and associated symptoms.
Used in Drug Development Research:
IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID serves as a key subject in ongoing research aimed at understanding its therapeutic applications. Its dual functionality in both cancer and inflammatory disease treatment makes it a promising candidate for the development of new pharmaceuticals.

InChI:InChI=1/C19H21F3N2O3S/c1-13(2)14-7-9-16(10-8-14)23-18(25)12-24(28(3,26)27)17-6-4-5-15(11-17)19(20,21)22/h4-11,13H,12H2,1-3H3,(H,23,25)

Upstream product

• 123531-52-2 imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester 
• 504-29-0 2-aminopyridine 

Downstream Products

• 1367714-24-6 C₂₀H₂₀F₂N₄O 
• 59182-04-6 1-(4-(imidazo[1,2-a]pyridin-3-yl)phenyl)ethan-1-one 
• 59182-08-0 4-(imidazo[1,2-a]pyridin-3-yl)benzonitrile 
• 92961-15-4 3-phenylimidazo[1,2-a]pyridine 
• 1338248-67-1 3-(4-methylphenyl)-imidazo[1,2-a]pyridine 
• 1338248-69-3 3-(3-methoxyphenyl)imidazo[1,2-a]pyridine 
• 274-76-0 imidazo[1,2-a]pyridine 
• 1426135-64-9 N-(5-cyano-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide 
• 1426133-94-9 tert-butyl 3-(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)azetidin-1-ylsulfonylcarbamate 
• 1426135-65-0 N-(5-(N'-hydroxycarbamimidoyl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide 
• 1426132-79-7 methyl 3-(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate 
• 1426132-87-7 N-(2-methyl-5-(5-(1-sulfamoylazetidin-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide 
• 1426132-90-2 methyl (3-(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)oxetan-3-yl)carbamate 
• 1426132-91-3 tert-butyl 3-(3-(4-fluoro-3-(imidazo[1,2-a]pyridine-3-carboxamido)phenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate 

Relevant academic research and scientific papers

Discovery of potent colony-stimulating factor 1 receptor inhibitors by replacement of hinge-binder moieties

Tumor-associated macrophages (TAMs) are predominantly associated with tumor growth. Colony-stimulating factor 1 receptor (CSF1R) acts as a key regulator of TAM survival and differentiation and is a molecular target for cancer therapies. Herein, novel CSF1

Identification of fused bicyclic heterocycles as potent and selective 5-HT2A receptor antagonists for the treatment of insomnia

A series of fused bicyclic heterocycles was identified as potent and selective 5-HT2A receptor antagonists. Optimization of the series resulted in compounds that had improved PK properties, favorable CNS partitioning, good pharmacokinetic properties, and significant improvements on deep sleep (delta power) and sleep consolidation.