62001-37-0Relevant academic research and scientific papers
LITHIATION ROUTES TO OXINDOLES AND 2-INDOLINETHIONES: PRECURSORS TO 2,2'-DITHIOBISINDOLES WITH TYROSINE KINASE INHIBITORY PROPERTIES
Rewcastle, Gordon W.,Denny, William A.
, p. 701 - 708 (2007/10/02)
N-Substituted oxindoles and 2-indolinethiones can be prepared by lithiation of carboxyl protected N,2-dimethylanilines followed by quenching with CO2 or CS2 respectively. 2-Indolinethione derivatives are also available via demethylation of 2-methylthioindoles, which are prepared by lithiation of N-substituted indoles and treatment with dimethyl disulfide.
Water-Tolerant Unstabilized Carbanion Equivalents: Bismuth(III) Chloride-Aluminum Promoted Alkylations of Immonium Cations to Amines in Aqueous Media
Katritzky, Alan. R.,Shobana, Navayath,Harris, Philip A.
, p. 4247 - 4248 (2007/10/02)
In the presence of bismuth(III) chloride-metallic aluminum, alkyl as well as allyl halides react with N-(alkylamino)benzotriazoles at 20 deg C in THF-water to give the corresponding homoalkylated amines in high yields.
Preparation of β-aminoesters from ketene silyl acetals and N-(alkylamino)benzotriazoles
Katritzky,Shobana,Harris
, p. 3999 - 4002 (2007/10/02)
A wide variety of β-aminoesters are prepared in good yields by the reaction of lithium ester enolates derived from ketene silyl acetals with N-(alkylamino)benzotriazoles. The secondary β-aminoesters readily cyclize to β-lactams (2-azetidinones) on deprotonation.
