62003-13-8

Basic information

• Product Name: 1,2,4-Triazine-3,5(2H,4H)-dione, 2-[(2-nitrophenyl)methyl]-
• Synonyms: 1,2,4-Triazine-3,5(2H,4H)-dione,2-[(2-nitrophenyl)methyl];2-(2-nitro-benzyl)-2H-[1,2,4]triazine-3,5-dione
• CAS NO: 62003-13-8
• Molecular Formula: C10H8N4O4
• Molecular Weight: 248.198
• Mol File: 62003-13-8.mol

Chemical Properties

• CAS DataBase Reference: 1,2,4-Triazine-3,5(2H,4H)-dione, 2-[(2-nitrophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Triazine-3,5(2H,4H)-dione, 2-[(2-nitrophenyl)methyl]-(62003-13-8)
• EPA Substance Registry System: 1,2,4-Triazine-3,5(2H,4H)-dione, 2-[(2-nitrophenyl)methyl]-(62003-13-8)

Safety Data

• Hazardous Substances Data: 62003-13-8(Hazardous Substances Data)

Relevant articles and documents

Anticoccidial derivatives of 6 azauracil. I. Enhancement of activity by benzylation of nitrogen 1. Observations on the design of nucleotide analogues in chemotherapy

Benzylation of 6-azauracil at N-1 (which corresponds to the point of attachment of the ribose phosphate unit in pyrimidine nucleotides) has been found to augment its anticoccidial activity fourfold. The high potency of 1-benzyl-6-azauracil is ascribed to a combination of intrinsic activity, efficient oral absorption, and a moderate rate of excretion. Metabolism experiments using 1-benzyl-6-azauracil labeled with 14C in the heterocycle and (separately) in the side chain showed that, in the drug accounted for, no cleavage had occurred. Additional activity increases were achieved by introducing small, electron-withdrawing substituents in the meta and/or para position(s) of the benzyl group. One of the most active derivatives, 1-(3-cyanobenzyl)-6-azauracil, is about 16 times as potent as 6-azauracil.