62003-87-6

Upstream product

• 85-44-9 phthalic anhydride 

Downstream Products

• 109653-18-1 N,N-phthaloyl-DL-thioleucine-S-(2,4,5-trichloro-phenyl ester) 
• 140244-54-8 2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-methyl-pentanoic acid p-tolylamide 
• 140244-55-9 2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-methyl-pentanoic acid (4-chloro-phenyl)-amide 
• 111114-03-5 Mesityl-(3-methyl-1-phthalimidobutyl)-keton 
• 140244-39-9 1-[1-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-methyl-butyl]-3-(2-methoxy-phenyl)-urea 
• 140244-38-8 1-[1-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-methyl-butyl]-3-(4-methoxy-phenyl)-urea 
• 140244-37-7 1-(4-Chloro-phenyl)-3-[1-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-methyl-butyl]-urea 
• 140244-36-6 1-[1-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-methyl-butyl]-3-p-tolyl-urea 
• 140244-59-3 α-phthalimido-γ-methyl-n-valeric acid phenylhydrazide 
• 140244-35-5 1-[1-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-methyl-butyl]-3-phenyl-urea 
• 112271-40-6 Phthaloyl-DL-leucin-anilid 

Relevant academic research and scientific papers

Bioinspired Deamination of α-Amino Acid Derivatives Catalyzed by a Palladium/Nickel Complex

An efficient bioinspired deamination method of both natural and unnatural amino acid derivatives has been developed. This method provides easy access to a wide variety of useful α, β-unsaturated carbonyl compounds. The reaction is realized with two transition metal catalysts (palladium and Nickel) in-easy handling procedure. A possible reaction pathway is also proposed and the control experiments support the involvement of the palladium-catalyzed inert sp3 C?H activation as one of the key steps. (Figure presented.).

Amino acid conjugates of aminothiazole and aminopyridine as potential anticancer agents: Synthesis, molecular docking and in vitro evaluation

Purpose: The development of resistance to available anticancer drugs is increasingly becoming a major challenge and new chemical entities could be unveiled to compensate this therapeutic failure. The current study demonstrated the synthesis of 2-aminothiazole [S3 (a-d) and S5(a-d)] and 2-aminopyridine [S4(a-d) and S6(a-d)] derivatives that can target multiple cellular networks implicated in cancer development. Methods: Biological assays were performed to investigate the antioxidant and anticancer potential of synthesized compounds. Redox imbalance and oxidative stress are hallmarks of cancer, therefore, synthesized compounds were preliminarily screened for their antioxidant activity using DPPH assay, and further five derivatives S3b, S3c, S4c, S5b, and S6c, with significant antioxidant potential, were selected for investigation of in vitro anticancer potential. The cytotoxic activities were evaluated against the parent (A2780) and cisplatin-resistant (A2780CISR) ovarian cancer cell lines. Further, Molecular docking studies of active compounds were performed to determine binding affinities. Results: Results revealed that S3c, S5b, and S6c displayed promising inhibition in cisplatin-resistant cell lines in comparison to parent cells in terms of both resistance factor (RF) and IC50 values. Moreover, S3c proved to be most active compound in both parent and resistant cell lines with IC50 values 15.57 μM and 11.52 μM respectively. Our docking studies demonstrated that compounds S3c, S5b, and S6c exhibited significant binding affinity with multiple protein targets of the signaling cascade. Conclusion: Anticancer activities of compounds S3c, S5b, and S6c in cisplatin-resistant cell lines suggested that these ligands may contribute as lead compounds for the development of new anticancer drugs.

Synthesis of Quaternary α-Fluorinated α-Amino Acid Derivatives via Coordinating Cu(II) Catalytic α-C(sp3)-H Direct Fluorination

A coordinating, copper-catalyzed direct α-C(sp3)-H fluorination method has been developed to prepare vital quaternary α-fluorinated α-amino acid derivatives. A Cu(II) catalytic SET oxidative addition mechanism is proposed, involving a key fluoride-coupled Cu(II) charge transfer complex. The protocol can tolerate a rich variety of α-amino acids, for which the auxiliary group is removed in high yield and substituted for the direct preparation of dipeptide derivatives with detachable, single absolute configurations of the target compounds.

Phthiobuzonum derivative and its preparation and use

The invention relates to a ftibamzone derivative and a preparation method and an application thereof, and belongs to the technical field of ftibamzone medicament synthesis. Pharmacological experiments prove that the ftibamzone derivative of the invention has obvious cytotoxic activity and antiviral activity, and can be used for treating viral diseases such as tumor, herpes, trachoma, and the like.

SULFUR YLIDES. 3. SYNTHESIS OF KETO-GROUP STABILIZED AMINO-CONTAINING SULFUR YLIDES FROM AMINO ACIDS

An effective path of synthesis was developed of new synthetic intermediates, the optically active, keto-group stabilized amino-substituted sulfur ylides.