62003-89-8

Usage

Uses

Used in Pharmaceutical Industry:
(3aR)-7α-Bromo-3a,4a,5,6,7,8,8aβ,9-octahydro-4aα,8,8-trimethylfuro[3,4-b][1]benzoxepin-1(3H)-one is used as a potential pharmaceutical candidate for [specific application reason, if known] due to its complex molecular structure and the presence of a bromine atom, which may contribute to its reactivity and interaction with biological systems.
Used in Chemical Research:
(3aR)-7α-Bromo-3a,4a,5,6,7,8,8aβ,9-octahydro-4aα,8,8-trimethylfuro[3,4-b][1]benzoxepin-1(3H)-one is used as a subject of chemical research for [specific research purpose, if known] to explore its properties, reactivity, and potential applications in various fields, including medicinal chemistry, material science, or other industries.

InChI:InChI=1/C15H21BrO3/c1-14(2)11-5-4-9-10(8-18-13(9)17)19-15(11,3)7-6-12(14)16/h4,10-12H,5-8H2,1-3H3/t10-,11-,12-,15-/m0/s1

Upstream product

• 77249-86-6 (+)-palisadin A 
• 85593-53-9 (3S,4S)-3-((E)-4,8-Dimethyl-nona-3,7-dienyl)-4-hydroxy-dihydro-furan-2-one 
• 22339-13-5 (E)-9-iodo-2,6-dimethylnona-2,6-diene 
• 85593-54-0 7,8-dihydroaplysistatin 
• 85593-53-9 (2R,3R)-2-homogeranyl-3,4-dihydroxybutanoic acid 1 4 lactone 
• 21677-96-3 geranyl cyanide 
• 69405-35-2 homogeranyl bromide 
• 6138-90-5 trans-geranyl bromide 
• 77250-03-4 (+)-12-hydroxy-palisadin B 
• 771531-68-1 (3aS,5S,7aS)-5-Bromo-4,4,7a-trimethyl-hexahydro-benzofuran-2-one 
• 771531-95-4 Toluene-4-sulfonic acid (2R,5aS,7S,9aS)-7-bromo-3-(4-methoxy-benzyloxymethyl)-6,6,9a-trimethyl-2,5,5a,6,7,8,9,9a-octahydro-benzo[b]oxepin-2-ylmethyl ester 
• 771531-77-2 Toluene-4-sulfonic acid (2R,5aS,7S,9aS)-7-bromo-3-hydroxymethyl-6,6,9a-trimethyl-2,5,5a,6,7,8,9,9a-octahydro-benzo[b]oxepin-2-ylmethyl ester 
• 771531-75-0 [(2R,5aS,7S,9aS)-7-Bromo-3-(4-methoxy-benzyloxymethyl)-6,6,9a-trimethyl-2,5,5a,6,7,8,9,9a-octahydro-benzo[b]oxepin-2-yl]-methanol 
• 771531-76-1 (2R,5aS,7S,9aS)-7-Bromo-2-bromomethyl-3-(4-methoxy-benzyloxymethyl)-6,6,9a-trimethyl-2,5,5a,6,7,8,9,9a-octahydro-benzo[b]oxepine 

Relevant academic research and scientific papers

Novel stereocontrolled approach to syn- and anti-oxepene-cyclogeranyl trans-fused polycyclic systems: Asymmetric total synthesis of (-)-Aplysistatin, (+)-Palisadin A, (+)-Palisadin B, (+)-12-hydroxy-Palisadin B, and the AB ring system of adociasulfate-2 a

A new stereocontrolled method for the formation of trans-anti cyclogeranyl-oxepene systems is described. The demanding stereochemistry is secured by stereoselective coupling of a cyclogeranyl tertiary alcohol with a 1,2-unsymmetrically substituted epoxide

CHIRAL, BIOMIMETIC TOTAL SYNTHESIS OF (-)-APLYSISTATIN.

The marine antineoplastic agent aplysistatin (6) has been prepared enantiospecifically.The key step is the biomimetic cyclization of (2R,3R)-2-homogeranyl-3,4-dihydroxybutanoic acid 1 4 lactone (3) with 2,4,4,6-tetrabromocyclohexa-2,5-dienone in nitromethane.

PALISADINS A,B AND RELATED MONOCYCLOFARNESOL-DERIVED SESQUITERPENOIDS FROM THE RED MARINE ALGA LAURENCIA cf. PALISADA

Five new monocyclofarnesol-derived sesquiterpenoids, along with the previously reported lactone aplysistatin, have been isolated from the tropical red alga Laurencia cf. palisada.The structures of these new compounds were defined by spectral and chemical analyses, including their partial interconversion with aplysistatin.