620103-22-2

Basic information

• Product Name: 4-[(2-NAPHTHYLOXY)METHYL]-1,3-THIAZOL-2-AMINE
• Synonyms: 4-[(2-NAPHTHYLOXY)METHYL]-1,3-THIAZOL-2-AMINE
• CAS NO: 620103-22-2
• Molecular Formula: C14H12N2OS
• Molecular Weight: 256.32
• Mol File: 620103-22-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-[(2-NAPHTHYLOXY)METHYL]-1,3-THIAZOL-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(2-NAPHTHYLOXY)METHYL]-1,3-THIAZOL-2-AMINE(620103-22-2)
• EPA Substance Registry System: 4-[(2-NAPHTHYLOXY)METHYL]-1,3-THIAZOL-2-AMINE(620103-22-2)

Safety Data

• Hazardous Substances Data: 620103-22-2(Hazardous Substances Data)

Upstream product

• 1616562-88-9 C₁₃H₁₁N₃O 
• 1147550-11-5 ammonium thiocyanate 

Relevant articles and documents

Method for performing driving synthesis of 4-alkyl or aryl-2-aminothiazole by visible light

The invention relates to a method for performing driving synthesis of 4-alkyl or aryl-2-aminothiazole by visible light. The method comprises the following steps: adding an olefin azide compound, ammonium thiocyanate and copper acetate into a solvent acetonitrile separately, performing driving reaction by using visible light with wavelength of 450 to 460 nm at the temperature of 25 DEG C for 20 to36 hours to obtain reaction liquid, and spin-drying the reaction liquid to obtain concentrate; and performing silica-gel column chromatography on the concentrate to obtain the 4-alkyl or aryl-2-aminothiazole. The method is high in yield, mild in condition and low in environmental pollution.

Visible-Light-Driven Synthesis of 4-Alkyl/Aryl-2-Aminothiazoles Promoted by in Situ Generated Copper Photocatalyst

Room-temperature synthesis of 4-alkyl/aryl-2-aminothiazoles from vinyl azides and ammonium thiocyanate was accomplished with the aid of copper salts and blue LED irradiation. Mechanism investigation indicates that in situ-formed Cu(NCS)2- plays dual important roles in the reaction: (1) as the photocatalyst to activate vinyl azides, (2) as the Lewis acid catalyst to promote ring opening of 2H-azirines with thiocyanide. This process is distinguished by high yields, mild conditions, low catalyst loadings, and tolerating numerous alkyl- and aryl vinyl azides with an array of functional groups.