620120-36-7Relevant academic research and scientific papers
Polystyrene-supported amino alcohol ligands for the heterogeneous asymmetric addition of phenyl zinc reagents to aldehydes
Castellnou, David,Fontes, Montserrat,Jimeno, Ciril,Font, Daniel,Solà, Lluís,Verdaguer, Xavier,Pericàs, Miquel A.
, p. 12111 - 12120 (2005)
A family of polystyrene-supported amino alcohols, characterized by a high catalytic activity in alkyl transfer from zinc to formyl groups has been successfully tested in the enantioselective addition of phenyl zinc reagents to aldehydes to afford chiral diarylmethanols. Enantioselectivities higher than 90% (mean ee 90.5%; eight examples) are recorded with aromatic aldehydes in what represents the first successful use of heterogeneous, polymeric reagents for enantiocontrol in the phenylation of aldehydes.
Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups
Rolland, Julien,Cambeiro, Xacobe C.,Rodriguez-Escrich, Carles,Pericas, Miquel A.
scheme or table, (2010/04/22)
A continuous flow system for the synthesis of enantioenriched diarylmethanols from aldehydes is described. The system uses an amino alcohol-functionalized polystyrene resin as the catalyst, and the arylating agent is conveniently prepared by transmetallation of triarylboroxins with diethylzinc.
Polystyrene-supported (R)-2-piperazino-1,1,2-triphenylethanol: A readily available supported ligand with unparalleled catalytic activity and enantioselectivity
Castellnou, David,Sola, Lluis,Jimeno, Ciril,Fraile, Jose M.,Mayoral, Jose A.,Riera, Antoni,Pericas, Miquel A.
, p. 433 - 438 (2007/10/03)
(Chemical Equation Presented) A very active and highly enantioselective catalytic resin, designed for minimal perturbation of the catalytic center by the polymer matrix, has been assembled in two steps from (S)-triphenylethylene oxide, piperazine, and Merrifield resin and tested in the enantioselective ethylation of aldehydes. 1-Arylpropanols of 94-95% ee are obtained in high yield by the use of only 2 mol % of catalytic resin at 0°C for 4 h.
