62019-36-7Relevant academic research and scientific papers
Anti-cancer potential of (1,2-dihydronaphtho[2,1-b]furan-2-yl)methanone derivatives
Islam, Kobirul,Pal, Kunal,Debnath, Utsab,Sidick Basha,Khan, Abu Taleb,Jana, Kuladip,Misra, Anup Kumar
supporting information, (2020/08/13)
A series of 1,2-dihydronaphtho[2,1-b]furan derivatives were synthesized by cyclizing 1-(aryl/alkyl(arylthio)methyl)-naphthalen-2-ol and pyridinium bromides in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in very good yield. The synthesized compounds were evaluated for their anti-proliferative potential against human triple negative MDA-MB-468 and MCF-7 breast cancer cells and non-cancerous WI-38 cells (lung fibroblast cell) using MTT experiments. Among 21 synthesized compounds, three compounds (3a, 3b and 3 s) showed promising anti-cancer potential and compound 3b was found to have best anti-proliferative activities based on the results of several biochemical and microscopic experiments.
Reactions of O-quinone methides with pyridinium methylides: A diastereoselective synthesis of 1,2-dihydronaphtho[2,1- b ]furans and 2,3-dihydrobenzofurans
Osyanin, Vitaly A.,Osipov, Dmitry V.,Klimochkin, Yuri N.
, p. 5505 - 5520 (2013/07/25)
A simple, general route to the 1,2-dihydronaphtho[2,1-b]furans and 2,3-dihydrobenzofurans substituted at C-2 by an acyl or aryl group, starting from phenolic Mannich bases and pyridinium ylides, has been developed. The mechanism of the reaction is believed to involve the formation of the o-quinone methide intermediate, Michael-type addition of the ylide to the o-quinone methide, followed by intramolecular nucleophilic substitution.
