6202-21-7

Basic information

• Product Name: 4-sulphanilamidosalicylic acid
• Synonyms: 4-sulphanilamidosalicylic acid;4-(p-Aminophenylsulfonylamino)-2-hydroxybenzoic acid;4-Sulfanilamidosalicylic acid;Metrasil;Einecs 228-263-9
• CAS NO: 6202-21-7
• Molecular Formula: C₁₃H₁₂N₂O₅S
• Molecular Weight: 308.30978
• EINECS: 228-263-9
• Mol File: 6202-21-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 576.4°C at 760 mmHg
• Flash Point: 302.4°C
• Appearance: /
• Density: 1.607g/cm³
• Vapor Pressure: 3.99E-14mmHg at 25°C
• Refractive Index: 1.715
• CAS DataBase Reference: 4-sulphanilamidosalicylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-sulphanilamidosalicylic acid(6202-21-7)
• EPA Substance Registry System: 4-sulphanilamidosalicylic acid(6202-21-7)

Safety Data

• Hazardous Substances Data: 6202-21-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H12N2O5S/c14-8-1-4-10(5-2-8)21(19,20)15-9-3-6-11(13(17)18)12(16)7-9/h1-7,15-16H,14H2,(H,17,18)

Upstream product

• 65-49-6 4-Aminosalicylic acid 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 345936-47-2 4-[(N-acetyl-sulfanilyl)-amino]-2-hydroxy-benzoic acid 
• 4136-97-4 methyl 4-aminosalicylate 
• 858479-96-6 4-[(N-acetyl-sulfanilyl)-amino]-2-hydroxy-benzoic acid methyl ester 
• 13684-28-1 2-hydroxy-4-nitro-benzoic acid methyl ester 
• 619-19-2 2-hydroxy-4-nitrobenzoic acid 
• 857762-33-5 2-hydroxy-4-sulfanilylamino-benzoic acid methyl ester 

Downstream Products

• 84907-40-4 N¹-(p-carboethoxy-m-hydroxyphenyl) sulfanylamide 

Relevant articles and documents

Synthesis of sulfanilamido-naphthoquinones as potential antituberculous agents

p-Aminobenzoic acid, the acid hydrazides of benzoic acid, salicylic acid and isonicotinic acid, and 4,4'-diaminodiphenyl sulfone were condensed with p-aminobenzenesulfonyl chloride to give the corresponding N1-substituted sulfanilamides. These molecules were then treated with 1,4-naphthoquinone to yield 2-substituted-1,4-naphthoquinones. The partition coefficient for the substituted quinones showed, in some cases, high diffusion rates to the organic phase, benzene, from physiological Tyrode's solution. These compounds are effective in low concentration in dioxane against the human sensitive strain of Mycobacterium tuberculosis H37 Rv. Sulfanilamides obtained from p-aminosalicylic acid and thiosemicarbazide failed to react with 1,4-naphthoquinone. These sulfanilamides also showed high activity against the same Mycobacterium.