62028-45-9Relevant academic research and scientific papers
Synthesis and Studies of Potential Inhibitors of CD73 Based on a Triazole Scaffold
Braka, Abdenour,Chaloin, Laurent,Cros-Perrial, Emeline,Grosjean, Félix,Jordheim, Lars Petter,Mathé, Christophe,Peyrottes, Suzanne,Uttaro, Jean-Pierre
supporting information, (2021/12/14)
The ecto-5′-nucleotidase CD73 is involved in the production of immunosuppressive adenosine in the tumoral microenvironment and recently became a validated target in immuno-oncology. To avoid formation of CD73-produced adenosine, several series of potential inhibitors of the target enzyme based on a triazole scaffold were synthetized and evaluated on recombinant purified hCD73 and in cell-based assays.
Diversity Oriented Synthesis of Allocolchicinoids with Fluoro and/or Oxygen Substituent(s) on the C-Ring from a Single Common Intermediate
Takubo, Keita,Furutsu, Kazunori,Ide, Takafumi,Nemoto, Hiroyuki,Ueda, Yuko,Tsujikawa, Kazutake,Ikawa, Takashi,Yoshimitsu, Takehiko,Akai, Shuji
supporting information, p. 1562 - 1576 (2016/04/05)
Allocolchicinoids, with a distinct polyoxygenated dibenzocycloheptane skeleton, attract much attention as potential candidate anticancer drugs. In this study, eight C-ring fluorinated analogues of allocolchicinoids, seven C-ring oxygen-substituted analogu
