62039-92-3

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLORO-3-(TRIFLUOROMETHYL)BENZYLAMINE is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique structure and reactivity allow for the creation of complex molecules with potential medicinal properties.
Used in Agrochemical Industry:
In the agrochemical sector, 4-CHLORO-3-(TRIFLUOROMETHYL)BENZYLAMINE is utilized as a precursor in the production of pesticides and other agrochemicals, enhancing crop protection and contributing to increased agricultural yields.
Used in Organic Synthesis:
4-CHLORO-3-(TRIFLUOROMETHYL)BENZYLAMINE is employed as a building block in organic synthesis for the assembly of a wide array of organic compounds. Its functional group compatibility and reactivity make it suitable for the construction of diverse chemical entities with various applications in research and industry.

InChI:InChI=1/C8H7ClF3N/c9-6-2-1-5(4-13)7(3-6)8(10,11)12/h1-3H,4,13H2

Downstream Products

• 885679-24-3 2-(4-chloro-3-trifluoromethyl-benzylcarbamoyl)-5-fluoro-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 913563-89-0 2-{[(5-chloro-2-methoxyphenyl)sulfonyl]amino}-N-(4-chloro-3-trifluoromethylbenzyl)pent-4-enamide 
• 648420-48-8 1-(4-chloro-3-trifluoromethyl-benzyl)-3-(7-hydroxy-naphthalen-1-yl)-urea 
• 1071526-31-2 N-(2-(7-(4-chloro-3-(trifluoromethyl)benzylamino)-3-(4-methoxyphenyl)-2-oxoquinoxalin-1(2H)-yl)ethyl)acetamide 
• 1155861-05-4 C₂₃H₂₆ClF₃N₂O₃S 
• 1224047-76-0 C₁₇H₁₃Cl₂F₃N₄O 
• 1224047-77-1 C₁₇H₁₃Cl₂F₃N₄O 
• 1240480-25-4 methyl 4-{[4-chloro-3-(trifluoromethyl)benzyl]amino}-6-nitroquinazoline-8-carboxylate 
• 924623-81-4 4-(4-Chloro-phenyl)-thiazole-2-carboxylic acid 4-chloro3-trifluoromethyl-benzylamide 
• 1260655-20-6 C₁₄H₁₂ClF₃N₂O₂ 
• 1383934-16-4 N-[4-chloro-3-(trifluoromethyl)benzyl]-2-ethoxy-6-hydroxybenzamide 
• 1422435-00-4 C₁₇H₁₀BrClF₃N₃O₂ 
• 1422435-06-0 C₁₇H₁₀ClF₃IN₃O₂ 
• 1385841-15-5 C₂₇H₂₅ClF₃N₅O₃ 

Relevant academic research and scientific papers

Process for producing trifluoromethylbenzylamines

The present invention relates to a process for producing a trifluoromethylbenzylamine represented by the general formula (1). This process includes the step of reducing an oxime represented by the general formula (2), where R1represents hydrogen atom, a halogen atom selected from the group consisting of fluorine, chlorine, bromine and iodine, or trifluoromethyl group, where R1is defined as above, and R2represents hydrogen atom, an alkyl group or an aralkyl group. With this process, the trifluoromethylbenzylamine can be produced with high selectivity.

Benzylamines: Synthesis and evaluation of antimycobacterial properties

The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra are described. The most active compounds in this test, N-methyl-3-chlorobenzylamine (MIC 10.2 μg/mL), N-methyl-3,5-dichlorobenzylamine (93, MIC 10.2 μg/mL), and N-butyl-3,5-difluorobenzylamine (MIC 6.4 μg/mL), also exhibited a marked inhibitory effect on Mycobacterium marinum and Mycobacterium lufu used for the determination of antileprotic properties. The combination of 93 with aminosalicylic acid, streptomycin, or dapsone exert marked supra-additive effects on M. tuberculosis H 37 Ra.