6204-40-6

Usage

Uses

Used in Organic Synthesis:
(Z)-4-[(benzyloxy)methyl]-2-(bromomethyl)-1,3-dioxolane is used as a reagent in organic synthesis for the construction of complex molecules, making it a valuable component in the development of novel chemical entities.
Used in Drug Discovery and Development:
(Z)-4-[(benzyloxy)methyl]-2-(bromomethyl)-1,3-dioxolane serves as a potential candidate in drug discovery and development due to its unique structure and reactivity, which can be exploited to create new pharmaceuticals with specific therapeutic properties.
Used in Pharmaceutical Production:
(Z)-4-[(benzyloxy)methyl]-2-(bromomethyl)-1,3-dioxolane is used as a building block in the production of pharmaceuticals, contributing to the synthesis of various drugs with targeted applications.
Used in Agrochemical Production:
(Z)-4-[(benzyloxy)methyl]-2-(bromomethyl)-1,3-dioxolane also finds application in the agrochemical industry, where it is utilized as a building block for the synthesis of agrochemicals, potentially leading to the development of new pesticides or other agricultural products.

InChI:InChI=1/C12H15BrO3/c13-6-12-15-9-11(16-12)8-14-7-10-4-2-1-3-5-10/h1-5,11-12H,6-9H2

Upstream product

• 7252-83-7 1-bromo-2,2-dimethoxyethane 
• 13071-59-5 3-benzyloxypropan-1,2-diol 
• 21668-09-7 sulpho-salicylic acid 
• 56552-80-8 (R)-3-benzyloxy-1,2-propanediol 

Relevant academic research and scientific papers

2-Hydroxymethyl-1,4-dioxane: Synthesis, resolution and determination of the absolute configurations of the enantiomers

2-Hydroxymethyl-1, 4-dioxane 3 was resolved via salt formation between its hydrogen phthalate and (R)- or (S)-1-phenylethylamine, selective crystallization of the resultant diastereomeric mixtures and subsequent recovery of its enantiomers by saponification. The progress of the resolution was followed by chiral HPLC and the absolute stereochemistry of the two enantiomers determined by comparison of their specific rotations with that of (R)-3 synthesized from enantiomerically pure (R)-1-O-benzylglycerol. The results of the synthesis of 3 and of its resolution are discussed and compared with those previously obtained for 1,2-isopropylidene glycerol evaluating the consequences of replacement of ispropylidene with an ethylene bridge.

Syntheses of All Four Stereoisomers Which Are Conformationally Constrained 1,4-Dioxanyl Analogs of the Antineoplastic Ether Lipid ET-18-OCH3

The syntheses of each of the four nearly optically pure stereoisomers of oxy>phosphocholine (2,3,2',3') were performed by two parallel divergent sequences.Phosphocholines 2 and 3 were prepared via the corresponding 5-heptadecyl-2-(hydroxymethyl)-1,4-dioxanes 21 and 23, respectively, from the completely regiospecific mixed-hydride reductions of (1R,4S,5S)-4-heptadecyl-3,6,8-trioxabicyclooctane (19) and (1R,4R,5S)-4-heptadecyl-3,6,8-trioxabicyclooctane (20), respectively.The two 4-heptadecyl-3,6,8-trioxabicyclooctanes 19 and 20 were the two separable products from an intramolecular cyclization reaction.By a parallel divergent sequence from the enantiomeric starting material, 3-O-benzyl-sn-glycerol (16'), the other two diastereomeric oxy>phosphocholines 2' and 3' were prepared.These four monocyclic oxy>phosphocholines (2,3,2',3') are conformationally constrained analogs of the antineoplastic and immunomodulatory ether lipid rac-2-O-methyl-1-O-octadecylglycero-3-phosphocholine (rac-1) (rac-ET-18-OCH3, rac-Edelfosine).

Halogenated derivatives of 1,3-dioxolane having mucolytic activity

Compounds useful as expectorants and fluidizers of tracheobronchial mucus having the specified formula are disclosed, the compounds having at least one bromine or iodine atom as a substituent. A process for preparing such compounds is also disclosed.