62054-72-2

Basic information

• Product Name: N-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]MORPHOLINE
• Synonyms: N-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]MORPHOLINE;4-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]MORPHOLINE;4-(4-MORPHOLINO)-3-NITROBENZOTRIFLUORIDE;BUTTPARK 45\09-99;Nitrotrifluoromethylphenylmorpholine;N-[2-Nitro-4-(trifluoromethyl)phenyl]morpholine 97%;N-[2-Nitro-4-(trifluoromethyl)phenyl]morpholine97%;1-Morpholino-2-nitro-4-(trifluoromethyl)benzene
• CAS NO: 62054-72-2
• Molecular Formula: C₁₁H₁₁F₃N₂O₃
• Molecular Weight: 276.21
• Mol File: 62054-72-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 34-36°C
• Appearance: /
• CAS DataBase Reference: N-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]MORPHOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]MORPHOLINE(62054-72-2)
• EPA Substance Registry System: N-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]MORPHOLINE(62054-72-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 62054-72-2(Hazardous Substances Data)

Usage

General Description

N-[2-Nitro-4-(trifluoromethyl)phenyl]morpholine is a chemical compound with the molecular formula C11H11F3N2O3. It is a nitro-substituted morpholine derivative that has a trifluoromethylphenyl group attached to the nitrogen atom. N-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]MORPHOLINE is often used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It possesses both a nitro group, which can undergo reduction reactions, and a trifluoromethyl group, which can undergo substitution reactions. N-[2-Nitro-4-(trifluoromethyl)phenyl]morpholine has applications in the pharmaceutical and agricultural industries and is used in the production of various organic compounds.

Upstream product

• 110-91-8 morpholine 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 367-86-2 1-fluoro-2-nitro-4-trifluoromethyl-benzene 

Downstream Products

• 446052-25-1 N-[2-(morpholin-4-yl)-5-(trifluoromethyl)phenyl]pyridine-3-carboxamide 
• 784-57-6 2-(morpholin-4-yl)-5-(trifluoromethyl)aniline 

Relevant articles and documents

Novel pyrazole amide compound and preparation thereof, and application of novel pyrazole amide compound in prevention and treatment of plant pathogenic diseases and pest killing

The invention relates to a novel pyrazole amide compound I and a preparation method thereof and application of the novel pyrazole amide compound I in prevention and treatment of plant pathogenic disease and pest killing. The novel pyrazole amide compound

Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity

Malaria is a devastating parasitic disease caused by parasites from the genus Plasmodium. Therapeutic resistance has been reported against all clinically available antimalarials, threatening our ability to control the disease and therefore there is an ongoing need for the development of novel antimalarials. Towards this goal, we identified the 2-(N-phenyl carboxamide) triazolopyrimidine class from a high throughput screen of the Janssen Jumpstarter library against the asexual stages of the P. falciparum parasite. Here we describe the structure activity relationship of the identified class and the optimisation of asexual stage activity while maintaining selectivity against the human HepG2 cell line. The most potent analogues from this study were shown to exhibit equipotent activity against P. falciparum multidrug resistant strains and P. knowlesi asexual parasites. Asexual stage phenotyping studies determined the triazolopyrimidine class arrests parasites at the trophozoite stage, but it is likely these parasites are still metabolically active until the second asexual cycle, and thus have a moderate to slow onset of action. Non-NADPH dependent degradation of the central carboxamide and low aqueous solubility was observed in in vitro ADME profiling. A significant challenge remains to correct these liabilities for further advancement of the 2-(N-phenyl carboxamide) triazolopyrimidine scaffold as a potential moderate to slow acting partner in a curative or prophylactic antimalarial treatment.

Trifluoromethyl arylamides with antileukemia effect and intracellular inhibitory activity over serine/arginine-rich protein kinases (SRPKs)

The serine/arginine-rich protein kinases (SRPKs) have frequently been found with altered activity in a number of cancers, suggesting they could serve as potential therapeutic targets in oncology. Here we describe the synthesis of a series of twenty-two tr