620567-92-2

Upstream product

• 3695-77-0 triphenylmethanethiol 
• 180973-22-2 (2E)-5-[(triphenylmethyl)thio]-2-pentenal 
• 150350-28-0 S-trityl 3-mercaptopropionaldehyde 
• 620567-86-4 (R)-4-Benzyl-3-((E)-(2R,3S)-2-chloro-3-hydroxy-7-tritylsulfanyl-hept-4-enoyl)-oxazolidin-2-one 

Downstream Products

• 620567-97-7 methyl (7R,11R,14R,17S,20S,E)-20-[(R)-1-(tert-butyldimethylsiloxy)ethyl]-7-hydroxy-11,14-diisopropyl-9,12,15,18-tetraoxo-1,1,1-triphenyl-17-tritylthiomethyl-2-thia-10,13,16,19-tetraazahenicos-5-en-21-oate 
• 620567-24-0 (7R,11R,14R,17S,20S,E)-20-[(R)-1-(tert-butyldimethylsiloxy)ethyl]-7-hydroxy-11,14-diisopropyl-9,12,15,18-tetraoxo-1,1,1-triphenyl-17-tritylthiomethyl-2-thia-10,13,16,19-tetraazahenicos-5-en-21-oic acid 
• 620568-02-7 (3S,6S,9R,12R,16S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-9,12-diisopropyl-16-((E)-4-tritylsulfanyl-but-1-enyl)-6-tritylsulfanylmethyl-1-oxa-4,7,10,13-tetraaza-cyclohexadecane-2,5,8,11,14-pentaone 
• 180973-26-6 (R,E)-3-hydroxy-7-(tritylthio)hept-4-enoic acid 

Relevant academic research and scientific papers

Total Synthesis of the Depsipeptide FR-901375

The first total synthesis of FR-901375, a novel bicyclic depsipeptide isolated from the fermentation broth of Pseudomonas chloroaphis No. 2522, has been achieved. The synthetic approach involves 13 reaction steps and is achieved in 12% overall yield. The key points in the successful synthetic strategy are a concise asymmetric synthesis of the key building block (3R,4E)-3-hydroxy-7-mercapto-4-heptenoic acid, a mild Mitsunobu macrolactonization step, and an I2-mediated deprotection with concomitant disulfide-bridge formation.