620595-36-0

Basic information

• Product Name: 2-Hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-benzaldehyde
• Synonyms: 2-Hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-benzaldehyde;(3-FORMYL-4-HYDROXYPHENYL)BORONIC ACID PINACOL ESTER
• CAS NO: 620595-36-0
• Molecular Formula: C₁₃H₁₇BO₄
• Molecular Weight: 248.08268
• Mol File: 620595-36-0.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 357.9±32.0 °C(Predicted)
• Appearance: /
• Density: 1.15±0.1 g/cm3(Predicted)
• PKA: 7.86±0.35(Predicted)
• CAS DataBase Reference: 2-Hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-benzaldehyde(620595-36-0)
• EPA Substance Registry System: 2-Hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-benzaldehyde(620595-36-0)

Safety Data

• Hazardous Substances Data: 620595-36-0(Hazardous Substances Data)

Upstream product

• 22532-62-3 4-bromosalicylaldehyde 
• 73183-34-3 bis(pinacol)diborane 
• 50-00-0 formaldehyd 
• 269409-70-3 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 
• 1761-61-1 5-bromosalicyclaldehyde 
• 68860-39-9 3-bromo-6-(methoxymethoxy)benzaldehyde 
• 620595-06-4 2-methoxymethoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzaldehyde 

Downstream Products

• 620595-07-5 2-[1,3]dithian-2-yl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenol 
• 125366-78-1 4,4'-dihydroxy-[1,1'-biphenyl]-3,3'-dicarbaldehyde 

Relevant articles and documents

Highly sensitive and selective fluorescent sensor for copper(II) based on salicylaldehyde Schiff-base derivatives with aggregation induced emission and mechanoluminescence

Three new Schiff-base derivatives with aggregation-induced emission (AIE) characteristics have been designed and successfully synthesized. Their photophysical properties in solution, aqueous suspension and the solid state were investigated systematically.

Strategic Design of Catalytic Lysine-Targeting Reversible Covalent BCR-ABL Inhibitors**

Targeted covalent inhibitors have re-emerged as validated drugs to overcome acquired resistance in cancer treatment. Herein, by using a carbonyl boronic acid (CBA) warhead, we report the structure-based design of BCR-ABL inhibitors via reversible covalent targeting of the catalytic lysine with improved potency against both wild-type and mutant ABL kinases, especially ABLT315I bearing the gatekeeper residue mutation. We show the evolutionarily conserved lysine can be targeted selectively, and the selectivity depends largely on molecular recognition of the non-covalent pharmacophore in this class of inhibitors, probably due to the moderate reactivity of the warhead. We report the first co-crystal structures of covalent inhibitor-ABL kinase domain complexes, providing insights into the interaction of this warhead with the catalytic lysine. We also employed label-free mass spectrometry to evaluate off-targets of our compounds at proteome-wide level in different mammalian cells.

Phosphine-catalyzed sequential (2+3)/(2+4) annulation of γ-vinyl allenoates: Access to the synthesis of chromeno[4,3-: B] pyrroles

A phosphine-catalyzed cascade (2+3)/(2+4) cyclization reaction of γ-vinyl allenoates with aldimine esters has been developed to provide a series of chromeno[4,3-b]pyrrole derivatives that contain three contiguous stereogenic centers. The method gives a good yield, excellent chemoselectivity and diastereoselectivity under mild conditions.

COLORANT COMPOSITION, PHOTOSENSITIVE RESIN COMPOSITION, PHOTO RESIST, COLOR FILTER, AND DISPLAY DEVICE

The present invention relates to a color material composition comprising a polymer including a unit represented by chemical formula 1, to a photosensitive resin composition comprising the same, to a photosensitive material, to a color filter, and to a dis