620595-36-0Relevant academic research and scientific papers
Highly sensitive and selective fluorescent sensor for copper(II) based on salicylaldehyde Schiff-base derivatives with aggregation induced emission and mechanoluminescence
Yang, Xiaoli,Zhang, Wenyan,Yi, Zihan,Xu, Hao,Wei, Jun,Hao, Lingyun
, p. 11079 - 11088 (2017)
Three new Schiff-base derivatives with aggregation-induced emission (AIE) characteristics have been designed and successfully synthesized. Their photophysical properties in solution, aqueous suspension and the solid state were investigated systematically.
Discrete triptycene-based hexakis(Metalsalphens): Extrinsic soluble porous molecules of isostructural constitution
Reinhard, Dennis,Zhang, Wen-Shan,Rominger, Frank,Curticean, Ronald,Wacker, Irene,Schr?der, Rasmus R.,Mastalerz, Michael
, p. 11433 - 11437 (2018)
In 2013 the concept of OMIMs (organic molecules of intrinsic microporosity) was introduced by McKeown et al. These OMIMs are constructed on the basis of rigid molecular cores such as triptycene, spirobifluorenes, and others. Like shape-persistent organic
Phosphine-catalyzed sequential (2+3)/(2+4) annulation of γ-vinyl allenoates: Access to the synthesis of chromeno[4,3-: B] pyrroles
Huang, You,Li, Xiaohu
supporting information, p. 9934 - 9937 (2021/10/12)
A phosphine-catalyzed cascade (2+3)/(2+4) cyclization reaction of γ-vinyl allenoates with aldimine esters has been developed to provide a series of chromeno[4,3-b]pyrrole derivatives that contain three contiguous stereogenic centers. The method gives a good yield, excellent chemoselectivity and diastereoselectivity under mild conditions.
Strategic Design of Catalytic Lysine-Targeting Reversible Covalent BCR-ABL Inhibitors**
Anantharajan, Jothi,Baburajendran, Nithya,Foo, Klement,Joy, Joma K.,Keller, Thomas H.,Kwek, Perlyn Z.,Li, Rong,Liu, Boping,Poulsen, Anders,Quach, David,Retna, Priya,Tang, Guanghui,Tee, Doris H. Y.,Wee, John L. K.,Yang, Wan-Qi,Yao, Shao Q.,Zhang, Chong-Jing
supporting information, p. 17131 - 17137 (2021/06/28)
Targeted covalent inhibitors have re-emerged as validated drugs to overcome acquired resistance in cancer treatment. Herein, by using a carbonyl boronic acid (CBA) warhead, we report the structure-based design of BCR-ABL inhibitors via reversible covalent targeting of the catalytic lysine with improved potency against both wild-type and mutant ABL kinases, especially ABLT315I bearing the gatekeeper residue mutation. We show the evolutionarily conserved lysine can be targeted selectively, and the selectivity depends largely on molecular recognition of the non-covalent pharmacophore in this class of inhibitors, probably due to the moderate reactivity of the warhead. We report the first co-crystal structures of covalent inhibitor-ABL kinase domain complexes, providing insights into the interaction of this warhead with the catalytic lysine. We also employed label-free mass spectrometry to evaluate off-targets of our compounds at proteome-wide level in different mammalian cells.
An AIE-active dual fluorescent switch with negative photochromism for information display and encryption
Li, Zhize,Liu, Lulu,Liu, Yifei
, p. 9872 - 9881 (2021/06/15)
A negative photochromic molecular switch with AIE and two-color fluorescence conversion properties was synthesized. This molecular switch was constructed by connecting two propyl sulfonic acid modified spiropyrans with one tetraphenylethene covalently, an
COLORANT COMPOSITION, PHOTOSENSITIVE RESIN COMPOSITION, PHOTO RESIST, COLOR FILTER, AND DISPLAY DEVICE
-
Paragraph 0220-0223, (2020/08/14)
The color material composition of claim 1, wherein the compound is represented by the following formula. A photosensitive material, a color filter and a display device are provided. (by machine translation)
COLORANT COMPOSITION, PHOTOSENSITIVE RESIN COMPOSITION, PHOTO RESIST, COLOR FILTER, AND DISPLAY DEVICE
-
Paragraph 0198-0201, (2020/10/09)
The present invention relates to a color material composition comprising a polymer including a unit represented by chemical formula 1, to a photosensitive resin composition comprising the same, to a photosensitive material, to a color filter, and to a dis
PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS
-
Page/Page column 36, (2017/01/02)
New pyrrolotriazinone derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks).
Direct C-C coupling of two Ni-salphen complexes to yield dinickel-disalphen complexes with symmetric and non-symmetric substitution-patterns
Bugenhagen,Prosenc
, p. 7460 - 7468 (2016/06/01)
The synthesis of symmetric and non-symmetric 5,5′-linked disalophen Ni(ii) complexes by the Suzuki-Miyaura-reaction is reported. Also, the synthesis and structural characterization of four Ni(ii)-precursor complexes are presented. The 5-Br-substituted mononuclear complexes 4 and 5 are coupled to the pinacolborane substituted complexes 6 and 7 yielding the four dinuclear dinickel complexes 8-11 in good yields. The crystal structure of dinuclear complex 8 was obtained revealing a coplanar arrangement between the two salophen fragments. Electronic spectra as well as DFT-calculations on the ground states and excitation energies are reported and they reveal a small coupling between the electronically saturated Ni-salophen complexes.
STK4 INHIBITORS FOR TREATMENT OF HEMATOLOGIC MALIGNANCIES
-
Paragraph 00686, (2017/01/09)
The application relates to compounds of Formula (I'): which modulate the activity of a kinase (e.g., STK4), a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease or disorder associated with the modulation of a kinase, such as STK4.
