620598-21-2

Basic information

• Product Name: trimethyl-[(1-triisopropylsilylindol-3-yl)methyl]ammonium iodide
• CAS NO: 620598-21-2
• Molecular Formula: C₂₁H₃₇IN₂Si
• Molecular Weight: 472.52185
• Mol File: 620598-21-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: trimethyl-[(1-triisopropylsilylindol-3-yl)methyl]ammonium iodide(CAS DataBase Reference)
• NIST Chemistry Reference: trimethyl-[(1-triisopropylsilylindol-3-yl)methyl]ammonium iodide(620598-21-2)
• EPA Substance Registry System: trimethyl-[(1-triisopropylsilylindol-3-yl)methyl]ammonium iodide(620598-21-2)

Safety Data

• Hazardous Substances Data: 620598-21-2(Hazardous Substances Data)

Upstream product

• 146886-51-3 1-(N-triisopropylsilyl-1H-indol-3-yl)-N,N-dimethylmethanamine 
• 74-88-4 methyl iodide 
• 13154-24-0 triisopropylsilyl chloride 
• 87-52-5 3-(Dimethylaminomethyl)indole 

Relevant articles and documents

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Cycloclavine is a clavine-type Ergot alkaloid noteworthy for its unique pentacyclic skeleton featuring a 3-azabicyclo[3.1.0]hexane substructure. A short convergent route to the racemic alkaloid is described which comprises only eight linear steps and requires only four chromatographic purifications. The two key building blocks can be prepared in high yield from commercially available starting materials. Two consecutive coupling reactions, namely a selective alkylation of a dienolate and a Heck reaction, are the key steps of the reaction sequence. (Chemical Equation Presented).

Somatostatin analogue compounds

Compounds having somatostatin activity of the following Formula I, 1wherein, R1 is aryl, substituted-aryl, and aryl-(lower-alkyl)-; R2 is lower alkyl, amino substituted lower alkyl, -carboxy-(lower-alkyl), -carbamic acid-(lower-alkyl) and -carboxy-(lower-alkyl)-aryl; and R3 and R4 are independently, lower-alkyl, aryl, substituted-aryl, (substituted-aryl)-(lower-alkyl)-, heteroaryl, (heteroaryl)-(lower-alkyl)-, substituted-heteroaryl, (substituted heteroaryl)-(lower-alkyl)-, heterocyclic, heterocyclic-(lower-alkyl)-, substituted-heterocyclic, (substituted-heterocylic)-(lower alkyl)-, -carboxy-(lower-alkyl), and -carboxy-(lower-alkyl)-aryl; or a pharmaceutically acceptable, ester, ether, or salt thereof; methods for their use; and preparation.

Methodology for the efficient synthesis of 3,4-differentially substituted indoles. Fluoride ion-induced elimination-addition reaction of 1-triisopropylsilylgramine methiodides

1-Triisopropylsilylgramine methiodide reacted smoothly with a variety of nucleophiles in the presence of tetrabutylammonium fluoride to give 3-substituted indoles. The 3,4-disubstituted indoles were efficiently synthesized by sequential use of 4-selective lithiation of 1-triisopropylsilylgramine and this new substitution reaction.