620598-71-2Relevant academic research and scientific papers
One-pot solvent-free reductive amination with a solid ammonium carbamate salt from CO2 and amine
Kang, Philjun,Lee, Kyu Myung,Lee, Won Koo,Lee, Kyu Hyung,Lee, Byeongno,Cho, Jaeheung,Hur, Nam Hwi
, p. 46203 - 46207 (2015/02/19)
Many amines are liquid and their handling is inconvenient compared with the corresponding solids. We transformed a liquid (S)-(-)-1-phenylethylamine 1 to the corresponding neutral solid form 2 by reacting with carbon dioxide. We performed reductive aminat
Facile synthesis of (S,S)-1,2-diacylamides and (S,S)-1,2-diamines with C2-symmetry
Ai, Lin,Xiao, Jichuan,Wang, Guo,Shen, Xiumin,Zhang, Cong
, p. 2859 - 2875 (2007/10/03)
A series of chiral vicinal tertiary diacylamides with C2- symmetry was synthesized from (S)-α-phenylethylamine, different aromatic aldehydes, and oxalyl chloride. The diacylamides obtained were then reduced to afford chiral vicinal diamines wit
Highly stereoselective Friedel-Crafts type cyclization. Facile access to enantiopure 1,4-dihydro-4-phenyl isoquinolinones
Philippe, Nicolas,Denivet, Fran?ois,Vasse, Jean-Luc,Sopkova-De Olivera Santos, Jana,Levacher, Vincent,Dupas, Georges
, p. 8049 - 8056 (2007/10/03)
The present report describes a stereoselective synthesis of 1,4-dihydro-4-phenyl isoquinolinones 5 based on a stereoselective Friedel-Crafts type cyclization. Cyclization precursors 1 were prepared in two steps, from the readily available (S)-mandelic acid, in 60-80% overall yield. The stereoselective electrophilic cyclization was accomplished in 20-86% yield and with 20-97% ee. In the course of this work, the presence of the amide carbonyl was found to be particularly important to guarantee a stereospecific process during the electrophilic aromatic substitution.
