620600-27-3

Basic information

• Product Name: 1-(4-((tert-butyldimethylsilyl)oxy)phenyl)propan-2-one
• Synonyms: 1-(4-((tert-butyldimethylsilyl)oxy)phenyl)propan-2-one
• CAS NO: 620600-27-3
• Molecular Weight: 264.44
• Mol File: 620600-27-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(4-((tert-butyldimethylsilyl)oxy)phenyl)propan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-((tert-butyldimethylsilyl)oxy)phenyl)propan-2-one(620600-27-3)
• EPA Substance Registry System: 1-(4-((tert-butyldimethylsilyl)oxy)phenyl)propan-2-one(620600-27-3)

Safety Data

• Hazardous Substances Data: 620600-27-3(Hazardous Substances Data)

Upstream product

• 770-39-8 4-methoxyphenylacetone 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 498548-56-4 2-(4-((tert-butyldimethylsilyl)-oxy)phenyl)acetaldehyde 
• 105460-59-1 methyl 2-{4-[(tert-butyldimethylsilyl)oxy]phenyl}acetate 
• 96013-75-1 2-(4{[tert-butyl(dimethyl)silyl]oxy}phenyl)ethanol 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 864160-19-0 2-(4-tert-butyldimethylsiloxyphenyl)propanol 

Downstream Products

• 620600-28-4 (1R)-2-{[2-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-1-methylethyl]amino}-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol 
• 864160-21-4 (2S,3S,4S,5R,6S)-3,4,5-Triacetoxy-6-{4-[2-(benzyl-methyl-amino)-propyl]-phenoxy}-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 87182-32-9 1-(4-hydroxyphenyl)-2-N-benzyl-N-methylaminopropane 
• 864160-20-3 1-(4-tert-butyldimethylsiloxyphenyl)-2-N-benzyl-N-methylaminopropane 

Relevant articles and documents

A deprotection procedure using SO3H silica gel to remove non-silyl protecting groups

Protecting groups are indispensable in organic synthesis and there is a great need for a variety of deprotection methods. Here, we investigated the scope of the application of a deprotection procedure using SO3H silica gel, which we have previously reported as a desilylation procedure. Under these conditions, -OMOM, -OSEM, -OTHP, and -OAc groups and dimethyl acetal were cleaved. Pivaloyloxy, benzyloxy and methoxy carbonyl groups remained intact and selective deprotection of TBS groups in the presence of other protecting groups was accomplished. We succeeded in cleaving an acetyl group on a secondary alcohol in a highly polar nortropine derivative. Our findings here provide another deprotection option and would be helpful in the synthesis of multifunctional compounds.

PHENETHANOLAMINE DERIVATIVES

The present invention relates to novel compounds of formula (I), or a salt, solvate, or physiologically functional derivative thereof, to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.