62061-70-5Relevant academic research and scientific papers
Development of Ketone-Based Brominating Agents (KBA) for the Practical Asymmetric α-Bromination of Aldehydes Catalyzed by Tritylpyrrolidine
Kano, Taichi,Maruoka, Keiji,Shimogaki, Mio,Takeshima, Aika
, p. 5959 - 5963 (2020)
Ketone-based brominating agents (KBA), ortho-substituted 2,2,2-tribromoacetophenones, have been developed, and the highly enantioselective and practical α-bromination of aldehydes with KBA was achieved. The reaction could be performed in the presence of only 0.1-1 mol % of catalyst without using a halogenated solvent at 0 °C and was found to be scalable.
Direct asymmetric bromination of aldehydes catalyzed by a binaphthyl-based secondary amine: Highly enantio- and diastereoselective one-pot synthesis of bromohydrins
Kano, Taichi,Shirozu, Fumitaka,Maruoka, Keiji
supporting information; experimental part, p. 7590 - 7592 (2010/11/18)
One-pot stereoselective synthesis of bromohydrins as a useful chiral building block was achieved by the reaction of Grignard reagents with optically active α-bromoaldehydes, which were in situ generated by direct asymmetric bromination of aldehydes cataly
A FACILE SYNTHESIS OF (S)-O-BENZYLGLYCIDOL
Takano, Seiichi,Sugihara, Takumichi,Kamikubo, Takashi,Ogasawara, Kunio
, p. 1587 - 1591 (2007/10/02)
A facile synthesis of (S)-O-benzylglycidol has been developed starting from (R)-1-O-benzylglycerol by sequential monohalogenation and cyclization.
