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620619-33-2

C10H5Cl2FN2O is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 620619-33-2 Structure

  • Basic information

    1. Product Name: C10H5Cl2FN2O
    2. Synonyms:
    3. CAS NO:620619-33-2
    4. Molecular Formula:
    5. Molecular Weight: 259.067
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 620619-33-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: C10H5Cl2FN2O(CAS DataBase Reference)
    10. NIST Chemistry Reference: C10H5Cl2FN2O(620619-33-2)
    11. EPA Substance Registry System: C10H5Cl2FN2O(620619-33-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 620619-33-2(Hazardous Substances Data)

620619-33-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 620619-33-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,2,0,6,1 and 9 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 620619-33:
(8*6)+(7*2)+(6*0)+(5*6)+(4*1)+(3*9)+(2*3)+(1*3)=132
132 % 10 = 2
So 620619-33-2 is a valid CAS Registry Number.

620619-33-2Relevant articles and documents

The synthesis and structure-activity relationship of pyridazinones as glucan synthase inhibitors

Ting, Pauline C.,Kuang, Rongze,Wu, Heping,Aslanian, Robert G.,Cao, Jianhua,Kim, David W.,Lee, Joe F.,Schwerdt, John,Zhou, Gang,Wainhaus, Samuel,Black, Todd A.,Cacciapuoti, Anthony,McNicholas, Paul M.,Xu, Yiming,Walker, Scott S.

scheme or table, p. 1819 - 1822 (2011/05/05)

A structure-activity relationship study of the lead 5-[4-(benzylsulfonyl) piperazin-1-yl]-4-morpholino-2-phenyl-pyridazin-3(2H)-one 1 has resulted in the identification of 2-(3,5-difluorophenyl)-4-(3-fluorocyclopentyloxy)-5-[4- (isopropylsulfonyl)piperazin-1-yl]-pyridazin-3(2H)-one 11c as a β-1,3-glucan synthase inhibitor. Compound 11c exhibited significant efficacy in an in vivo mouse model of Candida glabrata infection.

Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors

Suree, Nuttee,Yi, Sung Wook,Thieu, William,Marohn, Melanie,Damoiseaux, Robert,Chan, Albert,Jung, Michael E.,Clubb, Robert T.

experimental part, p. 7174 - 7185 (2010/03/30)

Methicillin resistant Staphylococcus aureus (MRSA) is a major health problem that has created a pressing need for new antibiotics. Compounds that inhibit the S. aureus SrtA sortase may function as potent anti-infective agents as this enzyme attaches virulence factors to the cell wall. Using high-throughput screening, we have identified several compounds that inhibit the enzymatic activity of the SrtA. A structure-activity relationship (SAR) analysis led to the identification of several pyridazinone and pyrazolethione analogs that inhibit SrtA with IC50 values in the sub-micromolar range. Many of these molecules also inhibit the sortase enzyme from Bacillus anthracis suggesting that they may be generalized sortase inhibitors.

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