620624-84-2Relevant academic research and scientific papers
Orthogonally protected monosaccharide building blocks for solid phase production of diversity oriented libraries
Rajaratnam, Premraj,Gupta, Praveer,Katavic, Peter,Kuipers, Krystle,Huyh, Ngoc,Ryan, Sarah,Falzun, Tania,Tometzki, Gerrald B.,Bornaghi, Laurent,Le Thanh, Giang,Abbenante, Giovanni,Liu, Ligong,Meutermans, Wim,Wimmer, Norbert,West, Michael L.
experimental part, p. 693 - 699 (2010/09/05)
The large scale synthesis of three orthogonally protected monosaccharide scaffolds suitable for use in the solid phase preparation of large diversity libraries is presented. Scaffolds based on 2-amino-2-deoxy-d-glucopyranose, 2-amino-2-deoxy-d-allopyranos
DISACCHARIDES FOR DRUG DISCOVERY
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Page/Page column 81, (2010/02/07)
Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function and other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalised about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.
