620627-85-2Relevant articles and documents
A versatile route to functionalized dilactones as monomers for the synthesis of poly(α-hydroxy) acids
Leemhuis, Mark,Van Steenis, Jan Hein,Van Uxem, Michelle J.,Van Nostrum, Cornelus F.,Hennink, Wim E.
, p. 3344 - 3349 (2007/10/03)
A synthetic pathway to functionalized six-membered dilactones structurally analogous to lactide is described. Through the use of orthogonal protecting groups, the synthesis of functionalized dilactones was performed in a straightforward way by cyanuric chloride-mediated cyclization of the corresponding linear α-hydroxy acid dimers. The synthesis of three different dilactones - methylglycolide, benzyloxymethylglycolide, and 2-benzyloxymethyl-5-methylglycolide - by the same procedure demonstrated the versatility of this route. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
