62070-34-2Relevant academic research and scientific papers
Highly regioselective one-pot, three-component synthesis of 1-aryl-3,4-substituted/annulated-5-(cycloamino)/(alkylamino)pyrazoles from β-oxodithioesters
Nandi, Ganesh C.,Singh, Maya S.,Ila, Hiriyakkanavar,Junjappa, Hiriyakkanavar
supporting information; experimental part, p. 967 - 974 (2012/03/27)
An efficient, highly regioselective protocol for the synthesis of the title compounds is reported. The reaction involves a one-pot, three-component cyclocondensation of β-oxodithioester, amine, and hydrazine in ethanol at reflux in the presence of a catal
A tandem reaction of 2-acetylmethylene-1,3-dithiolanes via fragmentation of the dithiolane ring in the presence of amines: a facile route to functionalized thioamides
Liang, Fushun,Li, Yan,Li, Dazhi,Cheng, Xin,Liu, Qun
, p. 7938 - 7941 (2008/03/14)
A facile and efficient route to functionalized thioamides has been developed by a tandem reaction of 2-acetylmethylene-1,3-dithiolanes via fragmentation of the dithiolane ring upon heating and in the presence of an amine.
Studies on Isoxazoles. XI. Pyrolyses of 4-Isoxazolin-3-thiones
Sugai, Soji,Tomita, Kauzo
, p. 103 - 109 (2007/10/02)
Novel pyrolysis reactions of 4-isoxazolin-3-thiones (X) are described, affording two regioisomeric 1,4-dithiins (III, IV) and thioacetamides (XI).Among the thioacetamides, N-methylbenzoylthioacetamide (XIe) was identical with an authentic sample prepared by the reduction of 2-methyl-5-phenyl-4-isoxazolin-3-thione (Xe) with thiophenol.The structures of the dithiins were deduced from the physicochemical data, especially the shielding and deshielding effects in the NMR spectra.A mechanism for the reactions is proposed by analogy with the thermal isomerization of 3-isoxazolones into 2-oxazolones.In order to account for the formation of the isomeric dithiins, a thiirene intermediate (II) was assumed to be involved in the reaction pathway.Keywords- pyrolysis of 4-isoxazolin-3-thiones; thermal ring transformations; 1,4-dithiins; thioacetamides; thiirene intermediates; shielding and deshielding effects; sulfur radicals
