62071-27-6

Upstream product

• 140-29-4 phenylacetonitrile 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 94-41-7 benzalacetophenone 

Downstream Products

• 854446-22-3 3-benzoyl-4-oxo-1,2,6-triphenyl-cyclohexanecarbonitrile 
• 872272-73-6 2,4,5-triphenyl-piperidine 
• 58305-72-9 3,5-dibenzyliden-4-oxo-1,2,6-triphenyl-cyclohexanecarbonitrile 
• 6341-61-3 4-oxo-1,2,6-triphenyl-cyclohexanecarbonitrile 
• 502187-52-2 2-bromo-3,4,6-triphenyl-pyridine 
• 3298-26-8 5-Oximino-2,3,5-triphenyl-pentansaeure-hydroxyimidat 
• 3298-21-3 5-Oximino-2,3,5-triphenyl-pentansaeure-amid 
• 6323-01-9 5-oxo-2-(3-oxo-1,3-diphenyl-propyl)-2,3,5-triphenyl-valeronitrile 
• 95812-77-4 2-bromo-5-oxo-2,3,5-triphenyl-valeronitrile 
• 70028-35-2 3,4,6-triphenyl-3,4-dihydro-1H-pyridin-2-one 

Relevant academic research and scientific papers

Access to 2-Amino-3-Arylthiophenes by Base-Catalyzed Redox Condensation Reaction Between Arylacetonitriles, Chalcones, and Elemental Sulfur

A straightforward access to 2-amino-3-arylthiophenes has been developed via one-pot two-step three-component reaction of arylacetonitriles, chalcones and elemental sulfur. The first step consists of a DBU-catalyzed formation of Michael adduct between aryl

New Application of 1,4-Dihydropyridine System: Michael Reactions Mediated by 1,4-Dihydropyridine-Enolate Adduct in Micellar Medium

1,4-dihydropyridine-acetophenone enolate adduct, in catalytic amount effects Michael reactions in aqueous cationic micelles of cetyltrimethylammonium bromide. The enolate, generated by dissociation of the adduct abstracts a proton from readily enolizable substrates to bring about the Michael reaction under mild conditions in fair to good yields without side products.

Water-soluble calixarenes as new inverse phase-transfer catalysts. Their application to aldol-type condensation and Michael addition reactions in water

Aldol-type condensation and Michael addition reactions of activated methyl and methylene compounds in aqueous NaOH solution have been developed without the need for any added organic solvents. The water-soluble calix[n]arenes, which contain trimethylammon

New aspects of Michael reaction: Reaction of 1,3-diarylpropenones with active cyano compounds

Ethyl 2-cyano-5-oxo-3,5-diarylpentanoates (7a-k) and 1,3,5-triaryl-2-aroyl-4-cyano-4-carboethoxycyclohexanols (6a-e,g,i,k) are obtained when the corresponding 1,3-diarylpropenones (1a-k) are reacted with ethyl cyanoacetate in the presence of different ratios of ethoxide ion.The cyclic products (6) are also obtained by treating the corresponding mono-condensation products (7) with sodium ethoxide.Furthermore, 3-aryl-4-benzoyl-2-phenylbutyronitriles (8) are obtained from the reaction of 1 with benzylcyanide in equimolar amounts in the presence of sodium ethoxide. 2-Benzoyl-4-cyano-1,3,4,5-tetraphenylcyclohexanol (9) is however, obtained when two moles of 1a are treated with one mole of benzylcyanide in the presence of ethoxide ion.The mono-condensation product 8 when treated with sodium ethoxide does not give 9.The cyclohexanol compound 11a is also obtained by the reaction of 1a with malononitrile.The structures of all the compounds have been established by elemental analysis and spectral data (IR, UV, 1H NMR and 13C NMR).

CONJUGATE ADDITION IN PHASE TRANSFER CATALYSIS CONDITIONS: REACTIONS OF α ENONES WITH ARYLACETONITRILES

Conjugate addition of arylacetonitriles 1-3 to α-enones 4-6 can be performed in liquid-liquid PTC conditions (toluene-saturated aqueous K2CO3 solution).The reaction is too slow with isophorone or mesityloxide to be synthetically useful.