62085-76-1Relevant academic research and scientific papers
Ag/P-Stereogenic Phosphine-Catalyzed Enantioselective 1,3-Dipolar Cycloadditions: A Method to Optically Active Pyrrolidines
Zhi, Mengna,Gan, Zhenjie,Ma, Rong,Cui, Hao,Li, Er-Qing,Duan, Zheng,Mathey, Fran?ois
supporting information, (2019/05/07)
A Ag/P-stereogenic phosphine-complex-catalyzed 1,3-dipolar cycloaddition of azomethine ylides with electron-deficient olefins is reported. In this reaction, highly functionalized pyrrolines with a spiro-quaternary stereogenic center were obtained in good yields (up to 99%) with excellent levels of diastereo-(up to >20:1 dr) and enantioselectivities (up to >99% ee). The chirality of adducts was controlled predominantly by the P-stereogenic phosphines.
Chemistry of acylals, part IV: BF3-catalyzed formation of substituted α,α′-bis(arylmethylidene)cycloalkanones from acylals and 1-cycloalkenyl trimethylsilyl ethers
Sydnes, Leiv K.,Pedersen, Gry S.,Holmelid, Bjarte,Sandberg, Marcel
, p. 3692 - 3696 (2008/09/19)
When mixtures of an aromatic aldehyde acylal and a I-cycloalkenyl trimethylsilyl ether in dichloromethane were treated with boron trifluoride at room temperature, the corresponding α,α′-bis(arylmethylidene) cycloalkanones were formed. The yield was sensitive to both the acetal/ether ratio and the structure of the acylal. The best results, up to 97% yield, were obtained when acylals containing a diacetoxy moiety were reacted with 1-cyclohexenyl trimethylsilyl ether with an acetal-to-ether ratio of 2:1. Georg Thieme Verlag Stuttgart.
