62089-34-3Relevant academic research and scientific papers
DERIVATIVES OF 1 H-PYRAZOLO[3,4-B]PYRIDINE AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISORDERS
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Paragraph 00283; 00355, (2015/03/13)
The present invention discloses compounds according to Formula (I): wherein R1, R2, R3, R4, L, and X are as defined herein. The present invention relates to compounds,methods for their production, pharmaceutical
NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISORDERS
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Paragraph 0553; 0554; 0670, (2015/03/28)
The present invention discloses compounds according to Formula I: wherein R1, R2, R3, R4, L, and X are as defined herein. The present invention relates to compounds, methods for their production, pharmaceutical
Syntheses of fenanthroviridone, gilvocarcin BE-12406X2, and antibiotic WS 599B based on the palladium and copper catalyzed coupling of organostannanes with bromoquinones
De Frutos, Oscar,Echavarren, Antonio M.
, p. 8953 - 8956 (2007/10/03)
A total synthesis of fenanthroviridone, gilvocarcin BE-12406X2, antibiotic WS 5995B is described based on the palladium and copper catalyzed coupling reaction of sterically hindered aryl stannanes with a 2-bromonaphthoquinone. Copyright (C) 199
Synthesis of antibiotics WS 5995 A and C and related compounds by palladium-catalyzed coupling of 2-bromonaphthoquinones with organostannanes
Echavarren,Tamayo,Cardenas
, p. 6075 - 6083 (2007/10/02)
The synthesis of arylnaphthoquinones can be performed simply by using as the key reaction the Pd(0)- and Cu(I)-catalyzed coupling of arylstannanes with 2-bromonaphthoquinones as the electrophiles. The palladium-catalyzed coupling reaction is general and allows for the functionalization of the unprotected quinone nucleus with alkyl, alkenyl, and aryl substituents. The coupling process tolerates the presence of a chelated peri hydroxyl and steric crowding of a 2,6-disubstituted arylstannane, although the preparation of a 2,6,2',6'-tetrasubstituted biaryl by coupling of 2-bromo-3,5-bis(acetyloxy)-1,4-naphthoquinone as the electrophile with 2,6-disubstituted arylstannanes was unsuccessful. The syntheses of quinonoid antibiotics WS 5995 A and C was accomplished by using this method as the key step. Benz[b]phenanthridinone 1, hypothetical intermediate in the biosynthesis of benz[b]phenanthridine alkaloids, was also prepared from antibiotic WS 5995 C or by addition of ammonia to the 2-aryl-1,4-naphthoquinone 41 followed by heterocyclization.
A New Synthesis of Defucogilvocarcin M
Hart, David J.,Merriman, Gregory H.
, p. 5093 - 5096 (2007/10/02)
A convergent synthesis of the title compound is described.The synthesis revolves around a MAD-mediated coupling of oxazoline 11 and naphthoquinone ketal 16 and requires eight steps via the longest linear sequence.
Synthesis of Antibiotic SS-228R. Strong Base Induced Cycloaddition of Homophthalic Anhydrides
Tamura, Yasumitsu,Fukata, Fumio,Sasho, Manabu,Tsugoshi, Teruhisa,Kita, Yasuyuki
, p. 2273 - 2277 (2007/10/02)
Two types of naphthacenediones, 1,6,7-trihydroxy-9-methyl- (2) and 1,6,10-trihydroxy-8-methyl-naphthacene-5,12-diones (4), were prepared by the cycloaddition of 8-methoxy-6-methyl- (9) and 5-methoxy-7-methylhomophthalic anhydrides (10) with 2-bromojuglone
