62093-52-1

Usage

Uses

Used in Pharmaceutical Research and Development:
(3-chlorophenyl)(9H-fluoren-2-yl)methanone is utilized as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of new molecules with specific properties and functions, contributing to the development of innovative drugs.
Used in Organic Synthesis:
In the field of organic synthesis, (3-chlorophenyl)(9H-fluoren-2-yl)methanone serves as a building block for the construction of complex organic molecules. Its versatility in participating in various chemical reactions makes it a valuable component in the synthesis of a wide range of organic compounds.
Used in Chemical Reactions:
(3-chlorophenyl)(9H-fluoren-2-yl)methanone's carbonyl functional group and chlorine-substituted phenyl group enable it to participate in numerous chemical reactions, such as nucleophilic addition, electrophilic substitution, and condensation reactions. This makes (3-chlorophenyl)(9H-fluoren-2-yl)methanone a useful reagent in the synthesis of various organic compounds.
Used in the Design of New Molecules:
The unique structure and features of (3-chlorophenyl)(9H-fluoren-2-yl)methanone make it an ideal candidate for the design of new molecules with specific properties and functions. It can be employed in the development of novel compounds for various applications, including pharmaceuticals, materials science, and chemical research.

Upstream product

• 86-73-7 9H-fluorene 
• 73686-48-3 3-chlorobenzoic acid 2-pyridinyl ester 
• 42428-03-5 (3-chlorophenyl)(1H-imidazol-1-yl)methanone 
• 535-80-8 3-chlorobenzoate 

Relevant academic research and scientific papers

2-(Trifluoromethylsulfonyloxy)pyridine as a Reagent for the Ketone Synthesis from Carboxylic Acids and Aromatic Hydrocarbons

A new reagent 2-(trifluoromethylsulfonyloxy)pyridine (TFOP) was prepared by the reaction of sodium salt of 2-pyridinol with trifluoromethylsulfonyl chloride in dioxane.The conpound TFOP in trifluoroacetic acid has been found to intermolecularly dehydrate from benzoic acid and aromatic hydrocarbons to give the corresponding benzophenones in high yield.It was further elucidated, in the reaction of fluorene, that a variety of carboxylic acids can be used as the acyl precursor for the aromatic ketone synthesis in conjunction with the TFOP/TFA system.This acylation procedure has been applied to the synthesis of 2-acylthiophenes, which are hard to prepare in a satisfactory yield by the classical Friedel-Crafts reaction using aluminum chloride as the catalyst.

N-Acylimidazoles-Trifluoroacetic Acid System as the Acylating Agent for Aromatic Hydrocarbons

N-Benzoylimidazole in trifluoroacetic acid could benzoylate electron-rich aromatic compounds, such as durene, p-dimethoxybenzene, mesitylene, anisole, thiophene, and fluorene, to give the corresponding benzophenone derivatives in good yields.It was further elucidated, in the reaction of fluorene, that N-acylimidazoles composed of a variety of acyl groups also could be used for the ketone synthesis.Therein, the imidazolides of aliphatic carboxylic acids or substituted benzoic acid with an electron-donating group gave ketones in high yields.The above-mentioned aromaticcompounds were also acylated with N-trifluoroacetylimidazole and free carboxylic acids in trifluoroacetic acid.The mechanism for these reactions was assumed to proceed via a mixed anhydride between trifluoroacetic acid.