62095-36-7Relevant academic research and scientific papers
Facile and general synthesis of quaternary 3-aminooxindoles
Marsden, Stephen P.,Watson, Emma L.,Raw, Steven A.
supporting information; experimental part, p. 2905 - 2908 (2009/05/30)
(Chemical Equation Presented) A novel approach to the valuable quaternary 3-aminooxindole skeleton is reported on the basis of intramolecular arylation of enolates of substituted amino acids. The reaction tolerates dialkyl- and arylalkylamines as well as a range of carbon substituents (primary and secondary alkyl, aryl). The cyclization of N-indolyl-substituted substrates is accompanied by direct C-H arylation of the indole, leading to indolo-fused benzodiazepines.
