620970-65-2Relevant academic research and scientific papers
Total Synthesis of the (+)-Antimycin A Family
Inai, Makoto,Nishii, Takeshi,Tanaka, Ayako,Kaku, Hiroto,Horikawa, Mitsuyo,Tsunoda, Tetsuto
experimental part, p. 2719 - 2729 (2011/06/23)
An asymmetric aldol reaction using Oppolzer's sultam has provided a practical and efficient synthetic route (15 steps, overall yield ca. 24%) to 12 compounds of the Antimycin A family and deisovalerylblastmycin, which were obtained in pure form on a 60-300 mg scale. In the syntheses, the nine-membered dilactone ring was constructed successfully by lactonization of a 2-pyridinethiol ester bearing a TIPS group on the 8-OH by using the (CuOTf) 2A·PhH complex. An asymmetric aldol reaction usingOppolzer's sultam has provided a practical and efficient synthetic route (15 steps, overall yield ca. 24%) to 12 compounds of the antimycin A family and deisovalerylblastmycin, which were obtained in pure form on a 60-300 mg scale.
Total synthesis of the (+)-antimycin A3 family: Structure elucidation of (+)-antimycin A3a
Nishii, Takeshi,Suzuki, Shiho,Yoshida, Katsuyoshi,Arakaki, Kozue,Tsunoda, Tetsuto
, p. 7829 - 7832 (2007/10/03)
(+)-Antimycin A3a (AA3a), one component of the natural antibiotic antimycin A3, was synthesized using an asymmetric aza-Claisen rearrangement. The stereochemistry at the 2′ position on the acyloxy side chain of AA3a/
