620971-39-3Relevant articles and documents
Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13
Freeman-Cook, Kevin D.,Reiter, Lawrence A.,Noe, Mark C.,Antipas, Amy S.,Danley, Dennis E.,Datta, Kaushik,Downs, James T.,Eisenbeis, Shane,Eskra, James D.,Garmene, David J.,Greer, Elaine M.,Griffiths, Richard J.,Guzman, Roberto,Hardink, Joel R.,Janat, Fouad,Jones, Christopher S.,Martinelli, Gary J.,Mitchell, Peter G.,Laird, Ellen R.,Liras, Jennifer L.,Lopresti-Morrow, Lori L.,Pandit, Jayvardhan,Reilly, Usa D.,Robertson, Donald,Vaughn-Bowser, Marcie L.,Wolf-Gouviea, Lilli A.,Yocum, Sue A.
, p. 6529 - 6534 (2008/09/17)
Explorations in the pyrimidinetrione series of MMP-13 inhibitors led to the discovery of a series of spiro-fused compounds that are potent and selective inhibitiors of MMP-13. While other spiro-fused motifs are hydrolytically unstable, presumably due to e
Triaryl-oxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors
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Page 42, (2010/02/05)
The present invention relates to triaryl-oxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula 1wherein said ring X is a 5-7 membered heterocyclic ring, and wherein A, Y, B, G, and W are as defined in the specification; and t