620985-93-5

Usage

Synonyms

MSI-1436

Chemical Class

Small molecule inhibitor

Target

Protein tyrosine phosphatase 1B (PTP1B)

Mechanism of Action

Inhibits PTP1B, which regulates insulin and leptin signaling pathways

Therapeutic Uses

Potential treatment for diabetes, obesity, and cancer

Anti-diabetic Effects

Demonstrated in animal studies

Obesity-related Metabolic Disorders

Shown potential as a treatment

Anti-tumor Activity

Exhibited in preclinical models

Research Status

Promising candidate for further research and development

Upstream product

• 813424-05-4 1-Methanesulfonyl-6-nitro-2,3-dihydro-1H-indole 
• 19727-83-4 6-nitroindoline 

Downstream Products

• 848951-60-0 (1-Benzyl-piperidin-4-yl)-(1-methanesulfonyl-2,3-dihydro-1H-indol-6-yl)-amine 

Relevant academic research and scientific papers

BENZAMIDE DERIVATIVE OR SALT THEREOF

There is provided a compound having a capsaicin receptor VR1 inhibitory activity and useful as a therapeutic agent for various pains including inflammatory pain and neurogenic pain, migraine, cluster headache, bladder diseases including overactive bladder

PHARMACEUTICALLY ACTIVE 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF PROTEIN KINASES

The present invention relates to 4,6-disubstituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, and pharmaceutical compositions containing at least one of said 4,6-di substituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof. Furhtermore, the present invention relates to the use of said 4,6-disubstituted aminopyrimidine derivatives as inhibitors for a protein kinase and a medium comprising at least one of said 4,6-disubstituted aminopyrimidine derivatives in an immobilized form and the use of said medium for enriching, purifying and/or depleting nucleotide binding proteins which bind to the immobilized 4,6-disubstituted aminopyrimidine derivatives.

Non-peptidic NPY Y2 receptor inhibitors

The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.