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621-63-6

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621-63-6 Usage

Uses

2,2-Diethoxyethanol is used in the synthesis of neooxazolomycin, part of the oxazolomycin family of antibiotics. Also used in the synthesis of pyrimidine based inhibitors of phosphodiesterase 7 (PDE7).

Check Digit Verification of cas no

The CAS Registry Mumber 621-63-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 1 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 621-63:
(5*6)+(4*2)+(3*1)+(2*6)+(1*3)=56
56 % 10 = 6
So 621-63-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H14O3/c1-3-8-6(5-7)9-4-2/h6-7H,3-5H2,1-2H3

621-63-6 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (L06282)  Glycolaldehyde diethyl acetal, stab. with ca 0.1% sodium carbonate, 98%   

  • 621-63-6

  • 2g

  • 398.0CNY

  • Detail
  • Alfa Aesar

  • (L06282)  Glycolaldehyde diethyl acetal, stab. with ca 0.1% sodium carbonate, 98%   

  • 621-63-6

  • 10g

  • 1328.0CNY

  • Detail
  • Alfa Aesar

  • (L06282)  Glycolaldehyde diethyl acetal, stab. with ca 0.1% sodium carbonate, 98%   

  • 621-63-6

  • 50g

  • 5302.0CNY

  • Detail

621-63-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,2-Diethoxyethanol

1.2 Other means of identification

Product number -
Other names Ethanol, 2,2-diethoxy-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:621-63-6 SDS

621-63-6Synthetic route

diethoxyacetaldehyde
5344-23-0

diethoxyacetaldehyde

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol 1.) 2 h, 0 deg C; 2.) r.t., 1 h;100%
acetoxyacetaldehyde diethylacetate
60468-85-1

acetoxyacetaldehyde diethylacetate

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether at 0℃;97%
acetoxy-1 triethoxy-1,2,2 ethane
103410-71-5

acetoxy-1 triethoxy-1,2,2 ethane

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether for 2h; Heating;94%
ethanol
64-17-5

ethanol

Glycolaldehyde
141-46-8

Glycolaldehyde

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

Conditions
ConditionsYield
With sodium hydroxide at 20℃; for 0.25h;91%
Ethyl diethoxyacetate
6065-82-3

Ethyl diethoxyacetate

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

Conditions
ConditionsYield
With sodium tetrahydroborate In dimethoxyethane, 1,2; ethanol at 50℃; for 7h; Heating / reflux;88.7%
methanol
67-56-1

methanol

sucrose

sucrose

A

D-Mannose
530-26-7

D-Mannose

B

(S)-Methyl lactate
27871-49-4

(S)-Methyl lactate

C

2-methoxyethyl vinyl ether
1663-35-0

2-methoxyethyl vinyl ether

D

methyl 2-hydroxybut-3-enoate
5837-73-0

methyl 2-hydroxybut-3-enoate

E

1,1-dihydroxyacetone
1186-47-6

1,1-dihydroxyacetone

F

Glyceraldehyde
56-82-6

Glyceraldehyde

G

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

Conditions
ConditionsYield
With potassium carbonate at 160℃; for 16h; Reagent/catalyst; Flow reactor;A n/a
B 72%
C n/a
D n/a
E n/a
F n/a
G n/a
2,5-diethoxy-[1,4]dioxane
66090-23-1

2,5-diethoxy-[1,4]dioxane

hydrogenchloride
7647-01-0

hydrogenchloride

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

Conditions
ConditionsYield
at 100℃;
2.5-diethoxy-1.4-dioxane

2.5-diethoxy-1.4-dioxane

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

Conditions
ConditionsYield
With hydrogenchloride at 100℃;
Bromoacetaldehyde diethyl acetal
2032-35-1

Bromoacetaldehyde diethyl acetal

alcoholic KOH

alcoholic KOH

A

ethyl acetate
141-78-6

ethyl acetate

B

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

Conditions
ConditionsYield
at 130℃;
diethoxyacetaldehyde
5344-23-0

diethoxyacetaldehyde

A

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

B

glyoxylic acid diethylacetal

glyoxylic acid diethylacetal

Conditions
ConditionsYield
With potassium hydroxide at 95℃;
1,1-diethoxy-2-iodoethane
51806-20-3

1,1-diethoxy-2-iodoethane

alcoholic KOH

alcoholic KOH

A

ethyl acetate
141-78-6

ethyl acetate

B

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

C

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

Conditions
ConditionsYield
at 100℃;
diethoxyacetaldehyde
5344-23-0

diethoxyacetaldehyde

KOH

KOH

A

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

B

glyoxylic acid diethylacetal

glyoxylic acid diethylacetal

Conditions
ConditionsYield
at 95℃; im Rohr;
1,1,2,2-tetraethoxyethane
3975-14-2

1,1,2,2-tetraethoxyethane

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 65 percent / ZnCl2 / 3 h / 90 °C
2: 94 percent / LiAlH4 / diethyl ether / 2 h / Heating
View Scheme
acrylaldehyde diethyl acetal
3054-95-3

acrylaldehyde diethyl acetal

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

Conditions
ConditionsYield
Multi-step reaction with 3 steps
2: durch Oxydation
3: n-KOH / 95 °C
View Scheme
Multi-step reaction with 3 steps
2: durch Oxydation
3: KOH / 95 °C
View Scheme
diethyl acetal
105-57-7

diethyl acetal

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: bromine
2: alcoholic KOH-solution
View Scheme
Multi-step reaction with 2 steps
1: durch Bromierung
2: alcoholic KOH-solution
View Scheme
4-methoxy-benzoyl chloride
100-07-2

4-methoxy-benzoyl chloride

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

4-methoxy-benzoic acid 2,2-diethoxy-ethyl ester
547752-15-8

4-methoxy-benzoic acid 2,2-diethoxy-ethyl ester

Conditions
ConditionsYield
With dmap; triethylamine at 20℃; for 16h;100%
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

1-(tert-butyldimethylsiloxy)-2,2-diethoxyethane
956317-82-1

1-(tert-butyldimethylsiloxy)-2,2-diethoxyethane

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 14h;100%
4-methoxy-benzoyl chloride
100-07-2

4-methoxy-benzoyl chloride

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

4-methoxy-benzoic acid 2,2-diethoxy-ethyl ester

4-methoxy-benzoic acid 2,2-diethoxy-ethyl ester

Conditions
ConditionsYield
With dmap; triethylamine In ethyl acetate at 0 - 20℃; for 16h;100%
With dmap; triethylamine In tert-butyl methyl ether at 0 - 20℃; for 16h;100%
thiocyanic acid
463-56-9

thiocyanic acid

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

2-mercapto-1,3-oxazole
32091-51-3

2-mercapto-1,3-oxazole

Conditions
ConditionsYield
In acetonitrile for 4h; Heating;100%
ethanethiol
75-08-1

ethanethiol

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

A

glycolaldehyde diethyl dithioacetal
67210-05-3

glycolaldehyde diethyl dithioacetal

B

1,1,2-tris-ethylsulfanyl-ethane
7038-14-4

1,1,2-tris-ethylsulfanyl-ethane

Conditions
ConditionsYield
With hydrogenchloride for 0.5h; Ambient temperature;A 98.6%
B 0.73%
C18H18N2O2

C18H18N2O2

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

C24H30N2O4

C24H30N2O4

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran98%
benzoyl chloride
98-88-4

benzoyl chloride

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

(benzoyloxy)acetaldehyde diethyl acetal
101268-52-4

(benzoyloxy)acetaldehyde diethyl acetal

Conditions
ConditionsYield
In pyridine at -20 - 30℃; for 167.833h;96.4%
With N-ethyl-N,N-diisopropylamine In pyridine 0 deg C, 1 h; r.t., 1.5 h;90%
With pyridine at 0 - 20℃; for 16h; Inert atmosphere;87%
With potassium hydroxide
tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

tert-Butyl-(2,2-diethoxy-ethoxy)-diphenyl-silane
139220-27-2

tert-Butyl-(2,2-diethoxy-ethoxy)-diphenyl-silane

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide95%
5-Bromo-2-chloropyrimidine
32779-36-5

5-Bromo-2-chloropyrimidine

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

5-bromo-2-(2,2-diethoxyethoxy)pyrimidine
864757-98-2

5-bromo-2-(2,2-diethoxyethoxy)pyrimidine

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 12h;94%
1-thiopropane
107-03-9

1-thiopropane

glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

A

glycolaldehyde dipropyl dithioacetal
81712-70-1

glycolaldehyde dipropyl dithioacetal

B

1,1,2-tris(propylthio)ethane
79414-77-0

1,1,2-tris(propylthio)ethane

Conditions
ConditionsYield
With hydrogenchloride for 0.5h; Ambient temperature;A 90.3%
B 0.76%
glycoaldehyde diethyl acetal
621-63-6

glycoaldehyde diethyl acetal

3-Chloro-2-methylpropene
563-47-3

3-Chloro-2-methylpropene

1,1-diethoxyethyl methallyl ether
251942-44-6

1,1-diethoxyethyl methallyl ether

Conditions
ConditionsYield
Stage #1: glycoaldehyde diethyl acetal With sodium hydride In tetrahydrofuran at 20℃; for 1h;
Stage #2: 3-Chloro-2-methylpropene In tetrahydrofuran Heating; Further stages.;
90%

621-63-6Relevant articles and documents

Efficient synthesis of α-branched purine-based acyclic nucleosides: Scopes and limitations of the method

Dra?ínsky, Martin,Frydrych, Jan,Janeba, Zlatko,Slavětínská, Lenka Po?tová

, (2020/10/02)

An efficient route to acylated acyclic nucleosides containing a branched hemiaminal ether moiety is reported via three-component alkylation of N-heterocycle (purine nucleobase) with acetal (cyclic or acyclic, variously branched) and anhydride (preferentially acetic anhydride). The procedure employs cheap and easily available acetals, acetic anhydride, and trimethylsilyl trifluoromethanesulfonate (TMSOTf). The multi-component reaction is carried out in acetonitrile at room temperature for 15 min and provides moderate to high yields (up to 88%) of diverse acyclonucleosides branched at the aliphatic side chain. The procedure exhibits a broad substrate scope of N-heterocycles and acetals, and, in the case of purine derivatives, also excellent regioselectivity, giving almost exclusively N-9 isomers.

PROCESS FOR THE PREPARATION OF 1,4-DIHYDROPYRIDINES AND COMPOUNDS USED IN THIS PROCESS

-

Page 11, (2010/02/08)

-

A ONE POT PROCESS FOR THE OBTENTION AND REACTIONS OF GLYOXAL MONOACETAL

Bernard, Didier,Doutheau, Alain,Gore, Jacques

, p. 1807 - 1814 (2007/10/02)

A THF solution of glyoxal monoacetal 1 is obtained by SWERN oxidation of 2,2-diethoxy 1-ethanol and directly submitted to diverse nucleophilic species; The expected adducts of 1 are obtained with acceptable yields.

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