62108-16-1

Basic information

• Product Name: 4-IODO-2,3-DIHYDRO-1H-INDOLE
• Synonyms: 4-IODO-2,3-DIHYDRO-1H-INDOLE;4-METHYL-2,3-DIHYDRO-1H-INDOLE;4-METHYL-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE;2,3-Dihydro-4-methyl-1H-indole;1H-Indole,2,3-dihydro-4-Methyl-;4-Methylindoline
• CAS NO: 62108-16-1
• Molecular Formula: C₉H₁₁N
• Molecular Weight: 245.06
• Mol File: 62108-16-1.mol
• Article Data: 20

Chemical Properties

• Melting Point: 0.1 °C
• Boiling Point: 300.6 °C at 760 mmHg
• Flash Point: 135.6 °C
• Appearance: /
• Density: 1.793 g/cm³
• Vapor Pressure: 0.00111mmHg at 25°C
• Refractive Index: 1.653
• Storage Temp.: 2-8°C(protect from light)
• PKA: 5.35±0.20(Predicted)
• CAS DataBase Reference: 4-IODO-2,3-DIHYDRO-1H-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODO-2,3-DIHYDRO-1H-INDOLE(62108-16-1)
• EPA Substance Registry System: 4-IODO-2,3-DIHYDRO-1H-INDOLE(62108-16-1)

Safety Data

• Hazardous Substances Data: 62108-16-1(Hazardous Substances Data)

Usage

General Description

4-Iodo-2,3-dihydro-1H-indole is a chemical compound that belongs to the indole family. It is a derivative of indole, a heterocyclic aromatic organic compound. The addition of an iodo group to the 4-position of the indole ring results in the formation of 4-Iodo-2,3-dihydro-1H-indole. This chemical compound has potential applications in medicinal chemistry and pharmaceutical research, as indole derivatives have been found to possess various biological activities such as anticancer, antimicrobial, and anti-inflammatory properties. Additionally, its unique structure and reactivity make it a valuable intermediate for the synthesis of more complex organic molecules. Overall, 4-Iodo-2,3-dihydro-1H-indole is a versatile compound with important implications in both research and development of novel drugs and materials.

InChI:InChI=1/C8H8IN/c9-7-2-1-3-8-6(7)4-5-10-8/h1-3,10H,4-5H2

Upstream product

• 16096-32-5 4-methyl-1H-indole 
• 859191-19-8 4-methyl-indoline-3-carboxylic acid 

Downstream Products

• 1294041-97-6 N-cyclohexyl-4-methylindoline-1-carboxamide 
• 1493759-05-9 C₃₂H₃₅NO₁₀ 
• 1493759-28-6 C₃₂H₃₇NO₉ 
• 903551-40-6 C₃₃H₃₇NO₉ 
• 16096-32-5 4-methyl-1H-indole 

Relevant articles and documents

Pd/C-Catalyzed transfer hydrogenation ofN-H indoles with trifluoroethanol and tetrahydroxydiboron as the hydrogen source

Under the guidance of the known mechanism of the hydrogenation of indoles and transfer hydrogenation with tetrahydroxydiboron (B2(OH)4), Pd/C catalyzed transfer hydrogenation ofN-H indoles with trifluoroethanol and tetrahydroxydiborane as the hydrogen source has been developed. This provides an efficient strategy and catalytic system for the reduction of un-activatedN-H indoles, andN-H indolines are obtained with good to excellent yields. In addition, a series of the isotopic labelling experiments were carried out to probe the mechanism.

Covalent Organic Frameworks toward Diverse Photocatalytic Aerobic Oxidations

Photoactive two-dimensional covalent organic frameworks (2D-COFs) have become promising heterogenous photocatalysts in visible-light-driven organic transformations. Herein, a visible-light-driven selective aerobic oxidation of various small organic molecules by using 2D-COFs as the photocatalyst was developed. In this protocol, due to the remarkable photocatalytic capability of hydrazone-based 2D-COF-1 on molecular oxygen activation, a wide range of amides, quinolones, heterocyclic compounds, and sulfoxides were obtained with high efficiency and excellent functional group tolerance under very mild reaction conditions. Furthermore, benefiting from the inherent advantage of heterogenous photocatalysis, prominent sustainability and easy photocatalyst recyclability, a drug molecule (modafinil) and an oxidized mustard gas simulant (2-chloroethyl ethyl sulfoxide) were selectively and easily obtained in scale-up reactions. Mechanistic investigations were conducted using radical quenching experiments and in situ ESR spectroscopy, all corroborating the proposed role of 2D-COF-1 in photocatalytic cycle.

CANCER TREATMENTS TARGETING CANCER STEM CELLS

Disclosed are compounds, methods, compositions, and kits that allow for treating cancer by, e.g., targeting cancer stem cells. In some embodiments, the cancer is colorectal cancer, gastric cancer, gastrointestinal stromal tumor, ovarian cancer, lung cancer, breast cancer, pancreatic cancer, prostate cancer, testicular cancer, or lymphoma. In some embodiments, the cancer is liver cancer, endometrial cancer, leukemia, or multiple myeloma. The compounds utilized in the disclosure are of Formula (0), (O'), and (I):