6211-15-0 Usage
Description
Morphine (sulfate hydrate) (Item No. 25955) is an analytical reference standard categorized as an opioid. It is a natural phenanthrene commonly used for its analgesic properties but has a high potential for addiction. Morphine is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.
Chemical Properties
White Solid
Uses
Different sources of media describe the Uses of 6211-15-0 differently. You can refer to the following data:
1. Principal alkaloid of opium.
This is a controlled substance (opiate). Analgesic (narcotic)
2. Principle alkaloid of opium.
This is a controlled substance (opiate). Analgesic (narcotic).
Acquired resistance
The analgesic effect of orally dosed morphine can equal that obtained by parenteral administration,
if proper doses are given. When given orally, the initial dose of morphine is usually 60 mg, followed by maintenance doses of 20 to 30 mg every 4 hours.
Addiction to clinically used morphine by the oral route generally is not a problem.
Mechanism of action
Morphine sulfate is the analgesic used most often for severe, acute, and chronic pain. Morphine is
a μ agonist and is a Schedule II drug. It is available in intramuscular, subcutaneous, oral, rectal,
epidural, and intrathecal dosage forms. The epidural and intrathecal preparations are formulated
without a preservative.Morphine is three- to six times more potent when given intramuscularly than
when given orally. The difference in activity results from extensive first-pass 3-O-glucuronidation of
morphine—an inactive metabolite. The half-life of intramuscularly dosed (10 mg) morphine is
approximately 3 hours. The dose of morphine, by any dosage route, must be reduced in patients
with renal failure and in geriatric and pediatric patients. The enhanced effects of morphine in renal
failure is believed to be caused by a buildup of the active 6-glucuronide metabolite, which depends
on renal function for elimination.
Check Digit Verification of cas no
The CAS Registry Mumber 6211-15-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,2,1 and 1 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 6211-15:
(6*6)+(5*2)+(4*1)+(3*1)+(2*1)+(1*5)=60
60 % 10 = 0
So 6211-15-0 is a valid CAS Registry Number.
InChI:InChI=1/2C17H19NO3.H2O4S.5H2O/c2*1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;1-5(2,3)4;;;;;/h2*2-5,10-11,13,16,19-20H,6-8H2,1H3;(H2,1,2,3,4);5*1H2/t2*10-,11+,13-,16-,17-;;;;;;/m00....../s1
6211-15-0Relevant articles and documents
MORPHINE SULFATE METHANOLIC SOLVATE, PROCESSES FOR MAKING SAME AND RELATED COMPOSITIONS AND METHODS FOR TREATING PAIN
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Paragraph 0078-0080, (2014/09/29)
Processes for reducing the amount of impurities, especially α,β-unsaturated ketones (ABUK), in materials containing morphine. Novel compounds, namely low ABUK morphine sulfate methanolic solvate, and a novel crystal form are also described. The method for making morphine sulfate methanolic solvate comprises mixing a morphine free base composition with methanol to form a solution and adding a liquid comprising sulfuric acid to the solution to form a morphine sulfate methanolic solvate precipitate. A method of making a morphine sulfate compound comprises drying the morphine sulfate methanolic solvate in the presence of water vapor, such that methanol molecules are removed and replaced with water vapor molecules. A composition for treating pain comprises the morphine sulfate compound and at least one pharmaceutically acceptable excipient. A method for treating pain comprises administering to a patient in need thereof the composition comprising the morphine sulfate compound and at least one pharmaceutically acceptable excipient.
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