62123-77-7

Upstream product

• 100126-95-2 isopropyl 2-(2-chlorophenyl)-2-hydroxyacetate 
• 26118-14-9 o-chlorobenzoylformic acid 
• 62123-75-5 ethyl 2-(2-chlorophenyl)-2-oxoacetate 

Downstream Products

• 1196988-57-4 (S)-iso-propyl α-hydroxy-α-(2-chlorophenyl)acetate 
• 1242001-70-2 (R)-isopropyl 2-(2-chlorophenyl)-2-hydroxyacetate. 
• 100126-95-2 isopropyl 2-(2-chlorophenyl)-2-hydroxyacetate 

Relevant academic research and scientific papers

Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air

Vanadium-catalyzed oxidative kinetic resolution (OKR) of methyl o-chloromandelate 2a, key intermediate of the well-known oral antiplatelet agent (S)-clopidogrel, was achieved by ambient air for the first time. The air oxidation system, which was composed of vanadium and tridentate Schiff base ligands derived from amino alcohols and salicylaldehyde derivatives, afforded an efficient and economic approach to the target intermediate with high enantioselectivities (>99% ee).

Enantio- and chemoselective Br?nsted-acid/Mg(nBu) 2 catalysed reduction of α-keto esters with catecholborane

The first enantio- and chemoselective Br?nsted-acid catalysed reduction of α-keto esters with catecholborane has been developed. The α-hydroxy esters were obtained under mild reaction conditions in virtually quantitative yields and excellent enantioselectivities. With slight modifications both enantiomers can be obtained without any loss of selectivity. This journal is the Partner Organisations 2014.