62128-28-3

Upstream product

• 33369-31-2 zomepirac 

Downstream Products

• 157847-07-9 2-chloro-1-[5-(4-chlorobenzoyl)-1,2,4-trimethyl-1H-pyrrol-3-yl]ethanone 
• 157847-14-8 5-Chloro-1-[5-(4-chloro-benzoyl)-1,2,4-trimethyl-1H-pyrrol-3-yl]-pentan-1-one 
• 62128-48-7 3-(4-chlorobenzoyl)-1,2,4-trimethylpyrrole 

Relevant academic research and scientific papers

Acid-Mediated Rearrangement of Acylpyrroles

N-Alkyl-2-acylpyrroles are converted by strong anhydrous acid to 1-alkyl-3-acylpyrroles.An equilibrium mixture of 2- and 3-acylpyrrole is produced by treatment of a 2- or 3-acyl NH pyrrole with acid.Pyrrolecarboxaldehydes similarly afford isomeric mixtures.A cross-ring migration, 7->8, is observed when the adjacent position is blocked.The mechanism of acid-mediated rearrangement of acylpyrroles is discussed.

Preparation of β-acyl pyrroles

A process for rearranging α-acyl pyrroles to β-acyl pyrroles which comprises reacting the former with an excess of a strong, anhydrous, non-oxidizing acid, preferably with heating.