62129-53-7

Basic information

• Product Name: BOC-3,5-DIIODO-L-TYROSINE
• Synonyms: BOC-3,5-DIIODO-TYR-OH;BOC-L-TYR(3,5-I2)-OH;BOC-TYR(3,5-I2)-OH;BOC-TYR(3,5-12)-OH;N-BOC-3,5-DIIODO-L-TYROSINE;N-ALPHA-T-BUTOXYCARBONYL-3,5-DIIODO-L-TYROSINE;N-ALPHA-TERT-BUTYLOXYCARBONYL-3,5-DIIODO-L-TYROSINE;N-tert-Butoxycarbonyl-3,5-diiodo-L-tyrosine
• CAS NO: 62129-53-7
• Molecular Formula: C₁₄H₁₇I₂NO₅
• Molecular Weight: 533.1
• Product Categories: Amino Acids
• Mol File: 62129-53-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: BOC-3,5-DIIODO-L-TYROSINE(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-3,5-DIIODO-L-TYROSINE(62129-53-7)
• EPA Substance Registry System: BOC-3,5-DIIODO-L-TYROSINE(62129-53-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 8
• HazardClass: IRRITANT
• Hazardous Substances Data: 62129-53-7(Hazardous Substances Data)

Usage

General Description

BOC-3,5-DIIODO-L-TYROSINE is a chemical compound with the molecular formula C16H18I2N2O4. It contains two iodine atoms and is derived from the amino acid tyrosine. This chemical is commonly used in the field of organic chemistry as a building block for the synthesis of various pharmaceuticals and bioactive compounds. It is often employed in the development of new drug molecules due to its unique structural properties and potential therapeutic applications. BOC-3,5-DIIODO-L-TYROSINE is also utilized in research and development activities related to drug discovery and medicinal chemistry.

Upstream product

• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 300-39-0 3,5-diiodo-l-tyrosine 
• 60-18-4 L-tyrosine 
• 128781-80-6 (S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-hydroxy-3,5-diiodophenyl)propanoate 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 128781-80-6 (S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-hydroxy-3,5-diiodophenyl)propanoate 
• 1197053-80-7 C₂₆H₂₇NO₅ 
• 1423720-70-0 (S)-tert-butyl 1-(3,5-diiodo-4-methoxyphenyl)-3-hydroxypropan-2-ylcarbamate 
• 1426447-00-8 (S)-tert-butyl 1-(3,5-diiodo-4-methoxyphenyl)-3-(methoxymethoxy)propan-2-ylcarbamate 
• 1426447-03-1 C₁₇H₂₇NO₇ 
• 1426447-04-2 C₁₇H₂₇NO₆ 
• 113850-74-1 methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3,5-diiodo-4-methoxyphenyl)propanoate 
• 154461-42-4 L-trans-epoxysuccinyl-3,5-diiodo-L-tyrosylamido(3-methyl)butane ethylester 
• 154415-62-0 L-trans-epoxysuccinyl-3,5-diiodo-L-tyrosylamido(3-methyl)butane ethylester 
• 154415-74-4 3,5-diiodo-L-tyrosylamido(3-methyl)butane 
• 620960-66-9 (S)-2-[(2S,3S,4R)-5-Azido-2-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-3,5-diiodo-phenyl)-propionylamino]-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-pentanoylamino]-3-(3,5-dibromo-4-hydroxy-phenyl)-propionic acid methyl ester 
• 620960-73-8 (S)-2-{(2S,3R,4S)-5-Azido-2-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-3,5-diiodo-phenyl)-propionylamino]-3,4-dihydroxy-pentanoylamino}-3-(3,5-dibromo-4-hydroxy-phenyl)-propionic acid methyl ester 
• 620960-60-3 N-tert-butoxycarbonyl-o,o'-diiodo-L-tyrosyl-L-threonyl-o,o'-dibromo-L-tyrosine methyl ester 
• 733054-76-7 N-tert-butoxycarbonyl-o,o'-diiodo-L-tyrosyl-L-allo-threonyl-o,o'-dibromo-L-tyrosine methyl ester 

Relevant articles and documents

An efficient synthesis of l-3,4,5-trioxygenated phenylalanine compounds from l-tyrosine

A new strategy for the synthesis of l-3,4,5-trioxygenated phenylalanine derivatives from l-tyrosine is developed for the first time. The approach, featuring the transformation of aryl diiodide to bis-phenol via a one-pot procedure including lithiation, boronation, and oxidation, is highly practical. By this robust protocol, N-protected l-3,5-bis(tert-butyldimethylsilyloxy)-4- methoxy-phenylalanine and l-3,4,5-trimethoxy-phenylalanine derivatives were obtained from l-tyrosine in 9 steps with 36-40% overall yields.

Characterization of thyroid hormone receptor α (TRα)-specific analogs with varying inner- and outer-ring substituents

Analogs of the TRα-specific thyromimetic CO23 were synthesized and analyzed in vitro using competitive binding and transactivation assays. Like CO23, all analogs bind to both thyroid hormone receptor subtypes with about the same affinity; however, modification of CO23 by derivatization of the 3′ position of the outer-ring or replacement of the inner-ring iodides with bromides attenuates binding. Despite lacking a preference in binding to TRα, all analogs display TRα-specificity in transactivation assays using U2OS and HeLa cells. At best, several agonists exhibit an approximately 6-12-fold preference in transactivation when tested with TRα in HeLa cells. One analog, CO24, showed in vivo TRα-specific action in a tadpole metamorphosis assay.

Adrenocorticotropin. 51. Synthesis and properties of analogues of the human hormone with tyrosine residues replaced by 3,5 diiodotyrosine

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