62135-86-8

Basic information

• Product Name: 3-OXO-4-P-TOLYL-BUTYRIC ACID ETHYL ESTER
• Synonyms: 3-OXO-4-P-TOLYL-BUTYRIC ACID ETHYL ESTER;4-Methyl-b-oxo-benzenebutanoic acid ethyl ester;Ethyl 3-oxo-4-(p-tolyl)butanoate;Ethyl 4-(4-methylphenyl)-3-oxobutanoate
• CAS NO: 62135-86-8
• Molecular Formula: C₁₃H₁₆O₃
• Molecular Weight: 220.26
• Product Categories: pharmacetical
• Mol File: 62135-86-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 309.2°C at 760 mmHg
• Flash Point: 132.8°C
• Appearance: /
• Density: 1.073g/cm³
• Vapor Pressure: 0.000648mmHg at 25°C
• Refractive Index: 1.506
• CAS DataBase Reference: 3-OXO-4-P-TOLYL-BUTYRIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-OXO-4-P-TOLYL-BUTYRIC ACID ETHYL ESTER(62135-86-8)
• EPA Substance Registry System: 3-OXO-4-P-TOLYL-BUTYRIC ACID ETHYL ESTER(62135-86-8)

Safety Data

• Hazardous Substances Data: 62135-86-8(Hazardous Substances Data)

Usage

General Description

3-Oxo-4-p-tolyl-butyric acid ethyl ester is a chemical compound that belongs to the class of organic compounds known as phenylbutyrates. It is a yellow liquid with a faint, sweet, and floral odor, and is commonly used in the fragrance industry. 3-OXO-4-P-TOLYL-BUTYRIC ACID ETHYL ESTER is also known for its use as a flavoring agent and in the production of perfumes and other cosmetic products. Its chemical structure includes a phenyl group, a butyric acid group, and an ethyl ester group, making it a versatile and valuable chemical in various industrial processes. Additionally, this compound has potential applications in pharmaceuticals and as a precursor in organic synthesis.

InChI:InChI=1/C13H16O3/c1-3-16-13(15)9-12(14)8-11-6-4-10(2)5-7-11/h4-7H,3,8-9H2,1-2H3

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 64-17-5 ethanol 
• 35675-44-6 4-methylphenylacetyl chloride 
• 14062-19-2 p-tolylacetic acid ethyl ester 
• 42201-84-3 1-ethoxy-1-(tert-butyldimethylsilyloxy)ethene 
• 622-47-9 4-tolylacetic acid 
• 6148-64-7 ethyl potassium malonate 
• 623-73-4 diazoacetic acid ethyl ester 
• 13107-39-6 2-(4-methylphenyl)oxirane 

Relevant articles and documents

Non-metal Lewis acid-catalyzed cross-Claisen condensation for β-keto esters

In this work, we disclose a new catalytic and highly chemoselective cross-Claisen condensation of esters. In the presence of TBSNTf2 as a non-metal Lewis acid, various esters can undergo cross-Claisen condensation to form β-keto esters which are important building blocks. Compared with the traditional Claisen condensation, this process, employing silyl ketene acetals (SKAs) as carbonic nucleophiles to achieve cross-Claisen condensation, requires mild conditions and has good tolerance of functional groups. This journal is

TAM family kinase and/or CSF1R kinase inhibitor and application thereof

The invention provides a novel inhibitor compound shown in a general formula (I). The compound has good kinase inhibition activity and can be used for preventing and/or treating diseases mediated by abnormal expression of TAM family kinase and/or a ligand thereof. The compound can target CSF1R kinase and can be used for preventing and/or treating diseases mediated by abnormal expression of a TAM family kinase receptor and/or a CSF1R kinase receptor and/or ligands thereof.

Synthesis of aryl β-ketoesters by opening of aryl epoxides with ethyl diazoacetate catalyzed by BF3OEt2

A facile synthesis of 4-aryl substituted β-ketoesters from the reaction aryl epoxides with ethyl diazoacetate, in presence of BF 3OEt2 has been described with excellent yields.